微小RNA对病毒性心肌炎调控机制的研究进展  

Research progress on the regulatory mechanism of microRNAs on viral myocarditis

作　　者：曲艺 张迪[1] 刘亚欣[1] Qu Yi;Zhang Di;Liu Yaxin(National Center for Cardiovascular Diseases and Fuwai Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing 100037, China)

机构地区：[1]北京协和医学院,中国医学科学院阜外医院国家心血管病中心,100037

出　　处：《中国心血管杂志》2021年第3期303-305,共3页Chinese Journal of Cardiovascular Medicine

基　　金：国家自然科学基金面上项目(81974042);临床与转化医学研究基金项目(2019XK320058)。

摘　　要：病毒性心肌炎的发生与病毒感染诱发的心肌炎症反应相关,但具体发病机制仍未明确。目前多个研究发现,部分微小RNA(microRNAs)在病毒性心肌炎患者中可出现显著上调或下调,提示其可能通过不同途径参与调控病毒性心肌炎的发病过程。因此,明确microRNAs在病毒性心肌炎发病中的机制可能为其提供新的临床诊断与治疗思路,增加新的治疗靶点。本文就microRNAs在病毒性心肌炎中的调控机制进行综述。The occurrence of viral myocarditis is associated with myocardial inflammation induced by viral infection while the specific pathogenesis is still unclear.At present,multiple studies have found that some microRNAs can be significantly up-regulated or down-regulated in patients with viral myocarditis,suggesting that they may be involved in regulating the pathogenesis of viral myocarditis through multiple ways.Therefore,clarifying the mechanism of microRNAs in the pathogenesis of viral myocarditis may provide new diagnostic and therapeutic ideas for its clinical diagnosis and increase new therapeutic targets.This article reviews the regulatory mechanism of microRNA in viral myocarditis.

关 键 词：病毒性心肌炎 微小核糖核酸 调控机制 

分 类 号：R54[医药卫生—心血管疾病]