甘油三酯葡萄糖指数与冠状动脉粥样硬化性心脏病关系的研究进展  

Research progress of triglyceride glucose index in coronary atherosclerotic heart disease

作　　者：王烁珊 吴敬国[1] 荆小莉[1] 张永威 唐皓[1] WANG Shuo-shan;WU Jing-guo;JING Xiao-li;ZHANG Yong-wei;TANG Hao(Department of General Medicine,the First Affiliated Hospital,Sun Yat Sen University,Guangzhou,Guangdong 510000,China)

机构地区：[1]中山大学附属第一医院全科医学规培基地,广东广州510000

出　　处：《中华全科医学》2021年第6期1008-1012,共5页Chinese Journal of General Practice

基　　金：国家自然科学基金(81372022)。

摘　　要：冠状动脉粥样硬化性心脏病(冠心病)迄今为止仍然是威胁人类健康的主要疾病之一。随着生活水平的改善,胰岛素抵抗发病率越来越高,胰岛素抵抗状态与冠心病发生及发展中的病理生理过程有着密切的关系,研究两者之间的内在关系对于冠心病的早期预防、治疗及随访至关重要。传统的胰岛素抵抗检测方法操作过程复杂、耗时,价格昂贵,不适合在社区医院开展,更无法在大规模人群中推广。近几年,甘油三酯葡萄糖指数(triglyceride-glucose index, TyG)作为一项简单的胰岛素抵抗替代标志物逐渐被重视。目前,有许多研究证实TyG指数反映胰岛素抵抗能力与传统胰岛素抵抗指标相比,具有可靠、高效及简便的特点。关于TyG指数与冠心病之间的研究层出不穷,有较多研究发现TyG指数升高与冠心病患者冠状动脉病变严重程度及不良心血管预后具有正相关性。本文归纳总结胰岛素抵抗状态与冠心病的发病及进展关系,胰岛素抵抗检测项目的研究进展及新型胰岛素抵抗指标——TyG指数与冠心病之间的关系。旨在提高基层医师对该指标的认识,并为社区全科医师利用这项指标提供更多的理论依据。期望未来社区医生可利用TyG指数这一项简单的标志物,做好冠心病高危人群的筛查及随访工作,降低冠心病的发病率和死亡率。Coronary heart disease(CHD) is still one of the main diseases threatening human health. With the development of economy, and the improvement of our living standards, the incidence of insulin resistance is increasing. Insulin resistance is closely related to the occurrence and development of CHD. The study of the internal relationship between insulin resistance and the pathophysiological process of CHD is of great importance for the early prevention, treatment and follow-up of CHD. The traditional testing method for insulin resistance is complicated, time-consuming and expensive, so it is not suitable to be carried out in community hospitals, cannot be promoted in large-scale populations. In recent years, triglyceride-glucose index(TyG index) as a simple insulin resistance replacement index has been paid more and more attentions. At present, many studies have confirmed that TyG index response insulin resistance is reliable, efficient and simple compared with traditional indicators of insulin resistance. Many studies have found that elevated TyG index is positively correlated with the severity of CHD and poor cardiovascular prognosis. This paper summarizes the relationship between insulin resistance and CHD, the research progress of insulin resistance detection index, and the relationship between TyG index and CHD. This article aims to improve the understanding of TyG index by general practitioners and provide more theoretical basis for them to use this insulin resistance indicator. We hope that we can use the simple marker of TyG index in the screening coronary heart disease risk groups and follow-up work for CHD, and reduce the incidence rate and mortality of CHD.

关 键 词：冠心病 胰岛素抵抗 甘油三酯葡萄糖指数 

分 类 号：R541.4[医药卫生—心血管疾病] R446[医药卫生—内科学]