肿瘤光治疗联合气体治疗纳米体系研究进展  

Advances in Research on Nanosystem of Tumor Phototherapy Combined with Gas Therapy

作　　者：顾瑞 张婷[2] 司伟丽 董晓臣[1] GU Rui;ZHANG Ting;SI Weili;DONG Xiaochen(Institute of Advanced Materials(IAM)&Key Laboratory of Flexible Electronics(KLOFE),Nanjing Tech University,Nanjing 211816,China;Jiangsu Cancer Hospital,Jiangsu Institute of Cancer Research,The Affiliated Cancer Hospital of Nanjing Medical University,Nanjing 210009,China)

机构地区：[1]南京工业大学先进材料研究院江苏省柔性电子重点实验室,江苏南京211816 [2]江苏省肿瘤医院江苏省肿瘤防治研究所南京医科大学附属肿瘤医院,江苏南京210009

出　　处：《药学进展》2021年第4期263-272,共10页Progress in Pharmaceutical Sciences

基　　金：国家自然科学基金面上项目(No.61775095,No.21975121);江苏省政策引导类计划(No.BZ2019014)。

摘　　要：光治疗作为一种非侵入性治疗方法在肿瘤治疗领域具有广阔的应用前景。然而,单一光治疗因其穿透深度低、氧气依赖性强、易引起免疫和炎症反应等缺点而在临床应用中受到极大限制。以一氧化氮、一氧化碳、硫化氢等为代表的气体治疗具有低毒性、内源性等优点,光治疗联合气体治疗不仅可以达到"1+1> 2"的治疗效果,还可以有效规避光治疗所引起的非必要性损伤。从光治疗、气体治疗以及光联合气体治疗3个方面进行介绍,阐述光治疗联合气体治疗所面临的挑战与机遇,重点讨论如何合理构建光联合气体治疗的纳米体系,以进一步促进其临床应用。As a non-invasive treatment,phototherapy shows important application prospect in cancer treatment.However,the clinical application of phototherapy is greatly restricted by its low penetration depth,strong oxygen dependence,and high incidence of immune and inflammatory reactions.Gas therapy based on endogenous gases(e.g.nitric oxide,carbon monoxide,hydrogen sulfide)possesses the advantages of low toxicity and endogeneity.The combination of phototherapy and gas therapy can not only achieve greater therapeutic effect,but also avoid unnecessary damage caused by phototherapy.This review introduces the application of phototherapy,gas therapy and synergistic therapy in tumor diagnosis and treatment,elaborates the challenges and opportunities of phototherapy combined with gas therapy,and discusses mainly the way to rationally construct a nanosystem for synergistic therapy to further promote its clinical application.

关 键 词：肿瘤 光治疗 气体治疗 协同治疗 

分 类 号：R944.9[医药卫生—药剂学] R454.2[医药卫生—药学]