磁性颗粒成像及其肿瘤诊疗研究进展  

Advances of Research on Magnetic Particle Imaging and Its Applications in Cancer Theranostics

作　　者：钟景 金志发 王楚天 冯林 刘文中[4] ZHONG Jing;JIN Zhifa;WANG Chutian;FENG Lin;LIU Wenzhong(Institute for Electrical Measurement Science and Fundamental Electrical Engineering,TU Braunschweig,Braunschweig 38106,Gentiany;Department of Radiology,Affiliated Jiangmen Hospital of Sun Yat-sen University,Jiangmen 529030,China;School of Mechanical Engineering and Automation,Beihang University,Beijing 100191,China;School of Artificial Intelligence and Automation,Huazhong University of Science and Technology,Wuhan 430074,China)

机构地区：[1]德国布伦瑞克工业大学电测量技术和基础电子技术研究所,下萨克森布伦瑞克38106 [2]中山大学附属江门医院放射科,广东江门529030 [3]北京航空航天大学机械工程及自动化学院,北京100191 [4]华中科技大学人工智能与自动化学院,湖北武汉430074

出　　处：《药学进展》2021年第4期273-282,共10页Progress in Pharmaceutical Sciences

基　　金：国家自然科学基金资助项目(No.61973132);科技部国家重点研发计划资助项目(No.2019YFB1309700)。

摘　　要：磁性颗粒成像(MPI)是一种全新的医学影像技术,具有高灵敏度、超快速和高空间分辨率等特点,能实时检测在体磁纳米粒子的三维空间分布。其中,彩色MPI技术不仅能实现磁纳米粒子浓度成像,也能实现局部微环境的温度和生物分子含量成像,已在以纳米医学为基础的肿瘤诊断和治疗等精准医疗领域表现出广泛的应用前景。目前,MPI技术仍存在纳米磁性物理机制不清晰和精密测量仪器信噪比瓶颈等难题。针对现有MPI技术,综述其发展历程及其在肿瘤诊疗等生物医学领域的应用前景。Magnetic particle imaging(MPI)is a new imaging technique with high sensitivity,high temporal resolution and spatial resolution,which allows to detect real-time 3 D spatial distribution of magnetic nanoparticles(MNPs).Color MPI allows to image not only the spatial distribution of magnetic nanoparticle concentration,but also the spatial distribution of in-situ temperature and biomolecule concentration,which has shown great promise in nanomedicine-based precision medicine,including cancer diagnostics and therapy(theranostics).Current MPI approaches are faced with two main challenges,including unclear underlying physical mechanism of nanomagnetism and signal-to-noise bottleneck of precise measuring instruments.Aiming at the current MPI technique,the MPI development and its applications in biomedicine such as cancer theranostics are reviewed.

关 键 词：磁性颗粒成像 磁纳米粒子 肿瘤诊疗 

分 类 号：R445[医药卫生—影像医学与核医学]