准顺磁超小铁氧体纳米对比剂的磁共振成像应用研究进展  

Advances of Research on Quasi-paramagnetic Ultrasmall Ferrite Contrast Agents for Magnetic Resonance Imaging

作　　者：苗玉清 张欢 彭明丽 樊海明 MIAO Yuqing;ZHANG Huan;PENG Mingli;FAN Haiming(College of Chemistry and Materials Science,Northwest University,Xi’an 710127,China;College of Life Sciences&School of Medicine,Northwest University,Xi'an 710069,China)

机构地区：[1]西北大学化学与材料科学学院,陕西西安710127 [2]西北大学生命科学与医学部,陕西西安710069

出　　处：《药学进展》2021年第4期283-289,共7页Progress in Pharmaceutical Sciences

基　　金：国家自然科学基金(No.81771981,No.22072115);陕西省自然科学基金(No.2020JQ610,No.2019JM143,No.2021JQ-459)。

摘　　要：受益于独特的磁学性质和较高的生物学相容性,铁氧体纳米材料作为影像对比剂在磁共振成像临床诊断和影像学研究中获得了广泛应用。特别是尺寸小于5 nm的准顺磁超小铁氧体纳米颗粒,具有高T1信号增强以及快速的肾清除能力,有望克服现有临床钆基T1对比剂在灵敏度和安全性方面的不足,发展成为下一代先进磁共振对比剂。从准顺磁超小铁氧体纳米对比剂的安全性、T_(1)-T_(2)信号增强特性、多模态成像及诊疗一体化应用等方面,综述近年来其在磁共振分子影像领域的研究进展及临床转化面临的挑战。Benefiting from their unique magnetic properties and good biosafety,ferrite nanomaterials are widely used in magnetic resonance imaging(MRI)clinical diagnostics and imaging studies.Quasi-paramagnetic ultrasmall ferrite nanoparticles with the size of less than 5 nm possess high T1 contrast power and rapid renal clearance,which can help to overcome the drawbacks of traditional gadolinium-based contrast agents with improved safety and efficacy,and are likely to become the next-generation MRI contrast agents.This review summarizes the research progress and challenges of clinical translation of quasi-paramagnetic ferrite nanoprobes as MRI T1 contrast agents in terms of safety,T1-T2 signal enhancement properties,multimodal imaging and integration of diagnosis and treatment.

关 键 词：准顺磁 超小铁氧体纳米颗粒 磁共振成像 对比剂 

分 类 号：R445.2[医药卫生—影像医学与核医学]