质子泵抑制剂药动学相互作用研究进展  

Research Progress of Pharmacokinetic Interactions of Proton Pump Inhibitors

作　　者：王巧红 张雅兰[1] 梁翠绿 张吟[1] WANG Qiaohong;ZHANG Yalan;LIANG Cuilyu;ZHANG Yin(Department of Pharmacy,The Second Affiliated Hospital of Fujian Medical University,Quanzhou 362000,China;College of Pharmacy,Fujian Medical University,Fuzhou 350000,China)

机构地区：[1]福建医科大学附属第二医院药学部,福建泉州362000 [2]福建医科大学药学院,福州350000

出　　处：《中国现代应用药学》2021年第9期1140-1147,共8页Chinese Journal of Modern Applied Pharmacy

基　　金：泉州市科技计划项目(2017Z012)。

摘　　要：目的探讨质子泵抑制剂药动学相互作用的研究进展。方法对国内外相关领域的文献进行归纳和总结。结果系统地对质子泵抑制剂通过提高胃内pH值和抑制P-糖蛋白影响相关药物吸收,抑制CYP2C19和CYP3A4影响相关药物代谢,抑制相关药物经肾清除等进行阐述。重点介绍了质子泵抑制剂与地高辛、伊曲康唑、酪氨酸激酶抑制剂、氯吡格雷、华法林、甲氨蝶呤、顺铂和培美曲塞的相互作用。结论临床用药应密切关注药物相互作用,避免质子泵抑制剂与此类药物联合使用或选用相互作用较小的质子泵抑制剂。OBJECTIVE To explore the progress of proton pump inhibitors pharmacokinetic interactions. METHODS To analyze and summarize the domestic and oversea research in the related area. RESULTS It systematically expounded that proton pump inhibitors affect the absorption of related drugs by increasing the pH in the stomach and inhibiting P-glycoprotein, and affect the metabolism of related drugs by inhibiting CYP2 C19 and CYP3 A4, and inhibiting the removal of related drugs by the kidney. The focus was on the interaction of proton pump inhibitors with digoxin, itraconazole, tyrosine kinase inhibitors, clopidogrel, warfarin, methotrexate, cisplatin and pemetrexed. CONCLUSION It should pay close attention to drug-drug interactions in clinical medication, and avoid the use of proton pump inhibitors in combination with such drugs, or select the proton pump inhibitors with lower interaction.

关 键 词：质子泵抑制剂 药物相互作用 药动学 地高辛 氯吡格雷 甲氨蝶呤 

分 类 号：R965.1[医药卫生—药理学]