血清HBD-2与OPN和IL-15对老年肺结核患者预后的预测价值  

Value of serum HBD-2,OPN and IL-15 indexes in prediction of prognosis of elderly patients with pulmonary tuberculosis

作　　者：何卫芬 孙岳琴[2] 徐红[3] HE Wei-fen;SUN Yue-qin;XU Hong(Xiaoshan District Hospital of Traditional Chinese Medicine,Hangzhou,Zhejiang 311201,China)

机构地区：[1]杭州市萧山区中医院预防保健科,浙江杭州311201 [2]杭州市萧山区第一人民医院产科,浙江杭州311201 [3]杭州市萧山区疾病预防控制中心门诊部,浙江杭州330109

出　　处：《中华医院感染学杂志》2021年第10期1502-1506,共5页Chinese Journal of Nosocomiology

基　　金：杭州市卫生计生委科技计划重点基金资助项目(2017Z2263)。

摘　　要：目的探讨老年肺结核患者人β-防御素-2(HBD-2)、骨桥蛋白(OPN)、白细胞介素-15(IL-15)血清表达情况及预后预测价值.方法选取2018年11月-2019年11月杭州市萧山区中医院诊治的肺结核老年患者83例为研究组,另选取同期老年健康体检者83名为对照组.入组后抽取血液样本测定血清HBD-2、OPN、IL-15表达情况,并给予研究组对应治疗,统计研究组与对照组,研究组不同病理特征及不同预后患者血清HBD-2、OPN、IL-15表达,并分析各指标对预后不良的预测价值.结果研究组血清HBD-2、OPN、IL-15水平均高于对照组(P<0.05);活动性肺结核患者血清HBD-2、OPN、IL-15水平高于潜伏性肺结核,痰涂片阳性患者血清HBD-2、OPN、IL-15水平高于痰涂片阴性患者,高热患者血清HBD-2、OPN、IL-15水平高于非高热患者(P<0.05);治疗后预后良好患者血清HBD-2、OPN、IL-15水平低于预后不良患者(P<0.05);治疗后三指标对肺结核预后不良预测AUC值均>0.7.结论老年肺结核患者血清HBD-2、OPN、IL-15异常高表达,且与患者病理特征、预后有关,可为临床诊治提供一定依据.OBJECTIVE To explore the expression levels of serum humanβ-defensin-2(HBD-2),osteopontin(OPN)and interleukin-15(IL-15)in elderly patients with pulmonary tuberculosis and analyze the value in prediction of prognosis.METHODS Totally 83 elderly patients with pulmonary tuberculosis who were treated in Xiaoshan District Hospital of Traditional Chinese Medicine from Nov 2018 to Nov 2019 were assigned as the study group,meanwhile,83 elderly people who received physical examination were set as the control group.The blood specimens were drawn to determine the expression levels of serum HBD-2,OPN and IL-15 after the enrollment.The study group was given symptomatic therapy,the expression levels of serum HBD-2,OPN and IL-15 were observed and compared between the study group and the control group and among the patients with different pathological features and different treatment outcomes in the study group.The values of the indexes in prediction of poor treatment outcomes were analyzed.RESULTS The levels of serum HBD-2,OPN and IL-15 of the study group were significantly higher than those of the control group(P<0.05).The levels of serum HBD-2,OPN and IL-15 of the patients with active tuberculosis were significantly higher than those of the patients with latent tuberculosis;the levels of serum HBD-2,OPN and IL-15 of the patients with positive sputum smear were significantly higher than those of the patients with negative sputum smear;the levels of serum HBD-2,OPN and IL-15 of the hyperthermia patients were significantly higher than those of the non-hyperthermia patients(P<0.05);the levels of serum HBD-2,OPN and IL-15 of the patients with favorable prognosis were significantly lower than those of the patients with poor prognosis after the treatment(P<0.05).The AUCs of all the three indexes were more than 0.7 in prediction of poor prognosis of the pulmonary tuberculosis patients after the treatment.CONCLUSION The serum HBD-2,OPN and IL-15 show abnormal high expression in the elderly patients with pulmonary tuberculosis,which is

关 键 词：老年 肺结核 人Β-防御素-2 骨桥蛋白 白细胞介素-15 病理特征 预后 

分 类 号：R521[医药卫生—内科学]