From Monovalent to Multivalent Vaccines, the Exploration for Potential Preventive Strategies Against Hand, Foot, and Mouth Disease(HFMD)  

作　　者：Xiangchuan He Miaomiao Zhang Chen Zhao Peiyong Zheng Xiaoyan Zhang Jianqing Xu 

机构地区：[1]Shanghai Public Health Clinical Center and Institutes of Biomedical Science,Shanghai Medical College,Fudan University,Shanghai 201508,China [2]Longhua Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China

出　　处：《Virologica Sinica》2021年第2期167-175,共9页中国病毒学（英文版）

基　　金：sponsored by the National Natural Science Foundation of China(81672018);the National 13th Five-Year Grand Program on Key Infectious Disease Control(2017ZX10202102);the 13th Five-Year National Science and Technology Major Project for infectious Diseases(2017ZX10305501-002);Shanghai Pujiang Program(19PJ1409100);the Technology Service Platform for Detecting High level Biological Safety Pathogenic Microorganism Supported by Shanghai Science and Technology Commission(18DZ2293000)。

摘　　要：Hand,foot,and mouth disease(HFMD)recently emerged as a global public threat.The licensure of inactivated enterovirus A71(EV-A71)vaccine was the first step in using a vaccine to control HFMD.New challenges arise from changes in the pathogen spectrum while vaccines directed against other common serotypes are in the preclinical stage.The mission of a broad-spectrum prevention strategy clearly favors multivalent vaccines.The development of multivalent vaccines was attempted via the simple combination of potent monovalent vaccines or the construction of chimeric vaccines comprised of epitopes derived from different virus serotypes.The present review summarizes recent advances in HFMD vaccine development and discusses the next steps toward a safe and effective HFMD vaccine that is capable of establishing a crossprotective antibody response.

关 键 词：Hand foot and mouth disease(HFMD) Inactivated whole virus vaccine Virus-like particles Multivalent vaccines Chimeric vaccines 

分 类 号：R392-33[医药卫生—免疫学]