Novel SFTSV Phylogeny Reveals New Reassortment Events and Migration Routes  

作　　者：Xiaoli Wu Mingyue Li Yanfang Zhang Boyun Liang Junming Shi Yaohui Fang Zhengyuan Su Mengmeng Li Wenjing Zhang Ling Xu Jun Wang Qiaoli Wu Shuang Tang Hualin Wang Tao Zhang Cheng Peng Xin Zheng Fei Deng Shu Shen 

机构地区：[1]State Key Laboratory of Virology and National Virus Resource Center,Wuhan Institute of Virology,Chinese Academy of Sciences,Wuhan 430071,China [2]University of Chinese Academy of Sciences,Beijing 100049,China [3]Department of Infectious Diseases,Institute of Infection and Immunology,Union Hospital,Tongji Medical College,HuaZhong University of Science and Technology,Wuhan 430022,China

出　　处：《Virologica Sinica》2021年第2期300-310,共11页中国病毒学（英文版）

基　　金：supported by the National Key R&D Programme of China(2018ZX10734404-010);the Nature Science Foundation of Hubei Province(2019CFB790 and 2018CFB471);the Innovation Team Project of Hubei Provincial Health Commission(WJ2019C003);the Open Research Fund of State Key Laboratory of Virology(2018IOV004);the Special Project of Technical Conditions(2060503)。

摘　　要：Severe fever with thrombocytopenia syndrome virus(SFTSV),the causative agent of a febrile human disease,was first identified from central and eastern provinces in China,and later in Japan and South Korea.Hubei Province is one of the major SFTS epidemic areas in the central part of China.This study reported the isolation of 11 new SFTSV strains from patients in Hubei Province collected in 2017.Extensive phylogenetic analyses were conducted based on the complete coding sequences of SFTSV segments including the new strains.It was suggested that five different SFTSV genotypes were circulating in Hubei,and 15 reassortment patterns and migration pathways correlated with each genotype were identified,which was more than previously recognized.Hubei Province was more involved in the evolutionary events of SFTSV than that previously thought in which the evolutionary events of SFTSV were reported to be independent from those in other epidemic regions.Further divergence of SFTSV strains was suggested by pairwise comparison of SFTSV sequences from each genotype and sequence identity normalized to representative strain in genotype C1.Subsequently,amino acid variations specific for genotype(s),strain(s),or cluster(s)were inspected,which may be related to differential biological activity of SFTSV strains/genotypes.In conclusion,we analyzed the current status of SFTSV phylogeny in Hubei Province and discussed the possible events correlated to SFTSV evolution.It provided an in-depth insight into SFTSV evolution,raising concerns for the use of proper SFTSV strains in future studies.

关 键 词：Severe fever with thrombocytopenia syndrome virus(SFTSV) GENOTYPES Genomic reassortment Virus migration Amino acid variations 

分 类 号：R373[医药卫生—病原生物学]