高分子材料载体在天然抗肿瘤药物中的研究进展  

Research progress on polymer material carrier in natural antitumor drugs

作　　者：王锐[1] 王晓桐 白皓天 王明月 郭一飞[2] WANG Rui;WANG Xiao-tong;BAI Hao-tian;WANG Ming-yue;GUO Yi-fei(Heilongjiang University of Traditional Chinese Medicine,Harbin 150000,China;Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100193,China)

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150000 [2]中国医学科学院北京协和医学院药用植物研究所,北京100193

出　　处：《中草药》2021年第10期3133-3141,共9页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(82074271);黑龙江省自然科学基金资助项目(H201472);黑龙江中医药大学研究生创新课题(2020yjscx055)。

摘　　要：高分子材料作为在天然抗肿瘤药物载体研究领域的热点,近10年来取得了飞速的发展,尤其是在如何降低药物的毒副作用,促进药物在体内的溶解和释放,提高生物利用度方面取得了突破性的进展。现如今高分子材料作为载体应用于天然抗肿瘤药物,提高了药物的抗肿瘤的疗效,使大部分天然抗肿瘤药物制剂的开发成为可能,推动了高分子材料载体在天然抗肿瘤药物中的应用。总结并讨论了近10年高分子材料载体在天然抗肿瘤药物中的研究情况,并为后续高分子材料药物载体的开发与应用提供参考。As a hot spot in the research field of natural anti-tumor drug carrier,polymer materials have made rapid development in the past 10 years,especially in reducing the toxic and side effects of drugs,promoting the dissolution and release of drugs in the body,and improving the bioavailability.Nowadays,polymer material is used as carrier in natural anti-tumor drugs,which improves the antitumor efficacy of drugs,makes it possible to develop most of natural anti-tumor drugs,and promotes the research progress of polymer material carrier in natural anti-tumor drugs.Polymer material carrier in natural anti-tumor drugs in the recent 10 years are summarized and discussed in this paper,in order to provide reference for subsequent development and application of polymer material drug carrier.

关 键 词：肿瘤 纳米药物 高分子材料 天然抗肿瘤药物 药物载体 

分 类 号：R285[医药卫生—中药学]