人参抗心律失常作用机制的研究进展  

Research progress on mechanism of antiarrhythmic action of Panax ginseng

作　　者：曹瑀莹 李劭恒 袁硕 张庆镐 刘丽萍 CAO Yu-ying;LI Shao-heng;YUAN Shuo;ZHANG Qing-gao;LIU Li-ping(Dalian Key Laboratory of Chronic Disease Research Center,Dalian University,Dalian 116622,China;People,s Hospital Affiliated to Medical University of Inner Mongolia Autonomous Region,Hohhot 010110,China;Yanbian University,Yanji 133022,China)

机构地区：[1]大连大学慢性病研究中心大连市重点实验室,辽宁大连116622 [2]内蒙古医科大学附属人民医院,内蒙古呼和浩特010110 [3]延边大学,吉林延吉133022

出　　处：《中草药》2021年第10期3157-3166,共10页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金面上项目(61671098);辽宁省自然科学基金资助项目(20180550388)。

摘　　要：人参Panax ginseng作为传统中药,具有较好的抗心律失常作用。从多离子通道阻滞作用、抑制炎症反应、抑制心肌纤维化和重构以及调节自主神经方面,对近10年人参、人参皂苷及含人参的中成药抗心律失常作用机制的研究进展进行综述。为以人参为基础,探究高效、低毒的抗心律失常中药的实验研究及临床用药提供参考。Panax ginseng,as a traditional Chinese herbal medicine,has a positive therapeutic effect on anti-arrhythmia.This article reviews the research progress of antiarrhythmic mechanism of ginsenoside and Chinese patent medicines containing P.ginseng in recent 10 years from the aspects of blocking ion channels,anti-inflammation,regulation of autonomic nerves activity,inhibition of myocardial fibrosis and remodeling.This article provides a reference for the experimental research and clinical use of anti-arrhythmia traditional Chinese medicine with high efficiency and low durg-toxicity.

关 键 词：人参 人参皂苷 人参中成药 心律失常 作用机制 

分 类 号：R282.710.5[医药卫生—中药学]