自噬在抗单纯疱疹病毒感染中的作用研究进展  

Research progress of autophagy in anti-herpes simplex virus infection

作　　者：邵青青 刘桐 王文佳 刘甜丽 金夕茗 陈琢[1,2] SHAO Qingqing;LIU Tong;WANG Wenjia;LIU Tianli;JIN Ximing;CHEN Zhuo(Institute of Integrated Traditional Chinese and Western Medicine,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,Hubei,China;Department of Integrated Traditional Chinese and Western Medicine,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,Hubei,China)

机构地区：[1]华中科技大学同济医学院附属同济医院中西医结合研究所,湖北武汉430030 [2]华中科技大学同济医学院附属同济医院中西医结合科,湖北武汉430030

出　　处：《上海中医药大学学报》2021年第3期79-83,共5页Academic Journal of Shanghai University of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(81874483)。

摘　　要：单纯疱疹病毒(HSV)可引起脑炎、口面部及生殖器感染等,发病率较高,且具有潜伏性。自噬是宿主抗HSV感染的重要机制之一。结合近年来国内外研究进展,从自噬的作用及与抗病毒的关系,自噬与HSV-1、HSV-2的相互作用等方面,阐述自噬在宿主细胞抗HSV感染中的作用,为HSV感染的相关研究和临床治疗提供参考。Herpes simplex virus(HSV)can cause encephalitis,orofacial and genital infection and other symptoms,with high incidence rate and latency.Autophagy is one of the important mechanisms of host resistance to HSV infection.Combined with the research progress at home and abroad in recent years,the role of autophagy in host cell resistance to HSV infection is elucidated,including the role of autophagy and its relationship with antiviral,the interaction between autophagy and HSV-1 or HSV-2,so as to provide reference for the research and clinical treatment of HSV infection.

关 键 词：自噬 HSV HSV-1 HSV-2 综述 

分 类 号：R373.11[医药卫生—病原生物学]