Wnt/β-catenin信号通路参与毛囊发育及周期循环调控的研究进展  

Research Progress on the Correlation between Wnt/β-catenin Signaling Pathway and Hair Follicle

作　　者：冯自强 孙永峰[1] 宋玉朴 周宇轩[1] 张磊 李晟毅 闫晓敏 许云鹏[1] FENG Ziqiang;SUN Yongfeng;SONG Yupu;ZHOU Yuxuan;ZHANG Lei;LI Shengyi;YAN Xiaomin;XU Yunpeng(College of Animal Science and Technology,Jilin Agricultural University,Jilin Changchun 130118,China;Jiangxi Animal Husbandry Technology Extension Station,Jiangxi Nanchang 330000,China)

机构地区：[1]吉林农业大学动物科学技术学院,吉林长春130118 [2]江西省畜牧技术推广站,江西南昌330000

出　　处：《中国畜牧杂志》2021年第6期88-95,共8页Chinese Journal of Animal Science

基　　金：吉林省科技厅重点研发项目(20180201034NY);吉林省科技厅中青年科技创新领军人才及团队项目(20200301035RQ);吉林省畜牧业管理局畜禽遗传资源开发利用项目(2020051000001);吉林省畜牧业管理局吉林省畜牧科技提质增效技术示范推广项目(202003)。

摘　　要：毛囊是动物皮肤重要的附属结构,具有复杂的形态变化和生理发育过程。毛囊的发育具有周期性循环特点,受到多方面要素的影响和调节。在遗传因素中,Wnt信号是毛囊生长的初始信号,参与形态发生及周期性循环的各个阶段,在毛囊基板发生、毛乳头功能发挥、毛囊周期性变化、毛囊干细胞增殖分化等过程发挥关键的调控作用。β-catenin是Wnt信号的分子开关,级联整合其他通路的信号,是Wnt信号转导途径中的核心环节。本文综述了Wnt/β-catenin信号通路调节毛囊发生发育的机制,为Wnt/β-catenin信号通路调控动物毛囊发生发育研究提供借鉴。Hair follicle is one of the essential appendages in animal skin with complex morphological changes and physiological development.The development of hair follicles has the characteristics of periodic circulation,and their influenced and regulated by various factors.Among genetic factors,the Wnt signal is the initial signal of hair follicle growth and participates in various stages of morphogenesis.It also plays critical regulatory role in physiological processes like the occurrence of DP function hair follicle periodicity in hair follicle substrates and the proliferation and differentiation of hair follicle stem cells.β-Catenin,as a molecular switch of Wnt signaling,is the core link of the Wnt signal transduction pathway which can cascade and integrate signals from other pathway.In this review,we are narrating the regulation mechanism of Wnt/β-catenin signaling pathway on hair follicle development,which provides reference for the research on regulation of Wnt/β-catenin signaling pathway on hair follicles development in animals.

关 键 词：毛囊发育 毛囊结构 毛囊周期 WNT/Β-CATENIN信号通路 周期调控 

分 类 号：S813.2[农业科学—畜牧学]