益生菌对腹腔镜胆囊切除患者术后肠道功能和炎症因子的影响  

作　　者：张健[1] 吴小昌[1] 万仁瑞 沈华[1] 谢平[1] 

机构地区：[1]浙江省湖州市中心医院(湖州师范学院附属中心医院),313000

出　　处：《浙江临床医学》2021年第5期712-714,共3页Zhejiang Clinical Medical Journal

基　　金：湖州市公益性应用研究项目(2017GYB40)。

摘　　要：目的分析日间腹腔镜胆囊切除术后患者口服益生菌对肠道功能和炎症因子的影响。方法回顾性分析118例行腹腔镜胆囊手术患者的临床资料,根据患者术后是否口服益生菌,分为2组,常规治疗为对照组(58例),常规治疗+益生菌口服为观察组(60例)。出院2周后,分析两组患者的肠道症状、肠道菌群失调发生率、肠道菌群和炎症因子水平变化。结果与对照组比较,观察组肠道症状、肠道菌群失调发生率明显降低(P<0.05);同时发现观察组双歧杆菌、乳酸杆菌水平明显升高,而拟杆菌、肠杆菌水平明显降低(P<0.05);对照组致炎因子IL-6、IL-22和TNF-a水平明显高于观察组(P<0.05),而抗炎因子IL-10低于观察组(P<0.05)。结论日间腹腔镜胆囊切除患者术后加用益生菌,能够降低肠道菌群失调、降低致炎症因子水平,改善肠道功能恢复,具有一定临床应用价值。Objective To evaluate the ffect of oral probiotics on intestinal function and inflammatory in patients after intra-day laparoscopic cholecystectomy.Methods Retrospective analysis was performed on patients who underwent laparoscopic cholecystectomy in the day center of our hospital,according to whether the patients took probiotics voluntarily after surgery or not,patients underwent laparoscopic cholcystectomy in the intra-day surgery center of our hospital were randomly selected.58 patients received routine postoperative treatment were selected as the control group.And 60 patients received postoperative treatment plus oral probiotics oral administration were selected as the treatment group.The incidence of diarrhea and intestinal flora imbalance,changes of flora,and inflammatory factors level in the two groups were analyzed.Results Compared with the control group,the incidence of diarhea and intestinal flora imbalance in the treatment group was signifcantly reduced(P<0.05).It was also found that the levels of bifidobacteria and lactobacillus in the treatment group were significantly increased,while those of bacteroides and enterobacteria were significantly decreased(P<0.05)。The levels of inflammatory cytokines IL-6,IL-22 and TNF-in the control group were significantly higher than those in the treatment group(P<0.05),while the levels of anti-inflammatory cytokines IL-10 were significantly lower than those in the treatment group(P<0.05).Conclusion The addition of oral probiotics after laparoscopic cholecystectomy can improve the imbalance of intestinal,reduce the level of inflammatory factors,and promote the recovery of intestinal function,which has certain clinical application value.

关 键 词：日间胆囊 益生菌 肠道功能 炎症因子 

分 类 号：R65[医药卫生—外科学]