真武汤联合左旋甲状腺素片治疗亚临床甲状腺功能减退症孕妇妊娠的效果  

Effect of Zhenwu Decoction and levothyroxine tablets on the pregnancy of women with subclinical hypothyroidism

作　　者：陈静 王琼 毛亚飞 孙娜芬 郑敏 陈华 CHEN Jing;WANG Qiong;MAO Yafei;SUN Nafen;ZHENG Min;CHEN Hua(Department of Pharmacy,Zhoushan Women and Children′s Hospital in Zhejiang Province,Zhoushan316000,China)

机构地区：[1]浙江省舟山市妇女儿童医院药剂科,浙江舟山316000

出　　处：《中国现代医生》2021年第14期147-150,共4页China Modern Doctor

基　　金：浙江省医药卫生科技计划项目(2017KY683)。

摘　　要：目的探讨真武汤联合左旋甲状腺素对亚临床甲状腺功能减退症孕妇妊娠结局的影响。方法选取2017年1月至2019年1月在我院收治的亚临床甲状腺功能减退症孕妇132例作为研究对象,应用随机数字表分为西药组和中西药联合组,每组各66例。西药组孕妇给予左旋甲状腺素进行治疗,中西药联合组给予真武汤联合左旋甲状腺素进行治疗。评估两组孕妇的临床效果及妊娠结局,比较两组孕妇治疗前后的中医症状积分、叶酸和血清甲状腺激素水平。结果治疗后,中西药联合组孕妇的临床总有效率为96.97%,明显高于西药组的77.27%,差异有统计学意义(P<0.05)。治疗后,两组甲状腺疼痛、疲劳、记忆力下降、易怒中医症状评分较治疗前显著下降,差异有统计学意义(P<0.05)。但治疗后两组FT3、FT4水平比较,差异无统计学意义(P>0.05)。治疗后,中西药联合组TSH水平显著低于西药组,叶酸水平显著高于西药组,差异有统计学意义(P<0.05)。治疗后,西药组孕妇的不良妊娠结局总发生率为18.18%,明显高于中西药联合组的4.55%,差异有统计学意义(P<0.05)。结论真武汤联合左旋甲状腺素治疗亚临床甲状腺功能减退症孕妇效果显著,明显改善患者临床症状,降低TSH水平及不良妊娠结局发生率。Objective To investigate the effect of Zhenwu Decoction combined with levothyroxine on pregnancy outcome of pregnant women with subclinical hypothyroidism.Methods A total of 132 pregnant women with subclinical hypothyroidism who were admitted to our hospital from January 2017 to January 2019 were selected as the research subjects.They were divided into the western medicine group and the Chinese and western medicine combination group using a random number table,with 66 cases in each group.Pregnant women in the western medicine group were given levothyroxine for treatment.The Chinese and western medicine combination group were given Zhenwu Decoction combined with levothyroxine for treatment.The clinical effects and pregnancy outcomes between the two groups were evaluated.The TCM symptom scores,folic acid,and serum thyroid hormone levels between the two groups before and after treatment were compared.Results After treatment,the total clinical effective rates of pregnant women in the western medicine group was 96.97%,which was higher than that of 77.27%in the Chinese and western medicine combination group.The difference between the two groups was statistically significant(P<0.05).After treatment,the scores of thyroid pain,fatigue,memory decline,and irritability in the two groups were significantly lower than before treatment,and the difference was statistically significant(P<0.05).However,there was no significant difference in the levels of FT3 and FT4 after the treatment between the two groups(P>0.05).After the treatment,the TSH level in the Chinese and western medicine combination group was significantly lower than that in the control group,and the folic acid level was significantly higher than that in the control group,and the difference was statistically significant(P<0.05).After the treatment,the total incidence of adverse pregnancy outcomes for pregnant women in the western medicine group was 18.18%,which was higher than that of 4.55%in the Chinese and western medicine combination group.The difference between t

关 键 词：真武汤 左旋甲状腺素 亚临床甲状腺功能减退症 妊娠结局 

分 类 号：R581.2[医药卫生—内分泌]