清热灵颗粒辅助治疗儿童流行性感冒热邪壅肺证78例临床观察  

Clinical observation on 78 cases of influenza in children with accumulation of pathogenic heat in lung syndrome treated by Qingreling Keli(清热灵颗粒)as adjuvant therapy

作　　者：沈健 SHEN Jian(Department of Pediatrics,Pinghu The First People's Hospital,Pinghu,Zhejiang,314200,China)

机构地区：[1]平湖市第一人民医院儿科,浙江平湖314200

出　　处：《中医儿科杂志》2021年第3期56-59,共4页Journal of Pediatrics of Traditional Chinese Medicine

摘　　要：目的观察清热灵颗粒辅助治疗儿童流行性感冒热邪壅肺证的临床效果。方法选取2018年10月至2019年10月平湖市第一人民医院儿科收治的175例流行性感冒热邪壅肺证患儿,按随机数字表法分为对照组87例和治疗组88例,治疗过程中治疗组脱落10例,对照组脱落12例,最终纳入研究对象共153例。对照组给予奥司他韦颗粒、蓝芩口服液、小儿肺热咳喘口服液口服,治疗组在对照组治疗方法的基础上加用清热灵颗粒口服,2组均以5 d为1个疗程,治疗1个疗程后统计临床疗效。结果治疗组总有效率为92.31%(72/78),对照组为76.00%(57/75),2组比较,差异有统计学意义(P<0.05)。治疗组咽痛、咳嗽缓解时间及体温恢复正常时间均显著短于对照组,2组比较,差异均有统计学意义(P<0.05)。治疗前,2组T淋巴细胞亚群CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)水平比较,差异无统计学意义(P>0.05),具有可比性;治疗后,2组CD4^(+)、CD4^(+)/CD8^(+)水平均明显升高,CD8^(+)水平明显下降,与同组治疗前比较,差异均有统计学意义(P<0.05),且治疗组升高/下降更显著,与对照组治疗后比较,差异也有统计学意义(P<0.05)。治疗组不良反应发生率为1.28%(1/78),对照组为3.99%(3/75),2组比较,差异无统计学意义(P>0.05)。结论清热灵颗粒辅助治疗儿童流行性感冒热邪壅肺证,能明显缩短临床症状消失时间,增强患儿机体免疫功能,疗效显著,且不良反应少,值得临床推广应用。Objective To observe the clinical efficacy of Qingreling Keli(清热灵颗粒)in adjuvant treatment of influenza in children with accumulation of pathogenic heat in lung syndrome.Methods From October 2018 to October 2019,175 cases of influenza in children with accumulation of pathogenic heat in lung syndrome admitted to pediatrics department of Pinghu The First People’s Hospital were chosen and divided into control group with 87 cases and treatment group with 88 cases according to random number table method.During the treatment,there were 10 drop-out cases in the treatment group and 12 drop-out cases in the control group,and 153 cases were included in the study.The control group was given oral administration of oseltamivir granules,Lanqin Koufuye(蓝芩口服液)and Xiaoer Feire Kechuan Koufuye(小儿肺热咳喘口服液),on this basis,the treatment group was added with oral administration of Qingreling Keli.Both groups took 5 days as a course of treatment,and we kept the clinical efficacy after 1 course of treatment.Results The total effective rate of the treatment group was 92.31%(72/78),that of the control group was 76.00%(57/75),and the difference was statistically significant between the 2 groups(P<0.05).The relieving time of sore-throat,cough and the time of temperature returning to normal in the treatment group were significantly shorter than those in the control group,and the differences were statistically significant between the 2 groups(P<0.05).Before treatment,the differences were not statistically significant in the levels of T-lymphocyte subsets CD4^(+),CD8^(+),CD4^(+)/CD8^(+)between the 2 groups(P>0.05),and they were comparable.After treatment,the levels of CD4^(+)and CD4^(+)/CD8^(+)significantly increased in the 2 groups compared with those before treatment,while the level of CD8^(+)significantly decreased,and the difference was statistically significant compared with the same group before treatment(P<0.05),moreover,the treatment group increased or decreased more significantly,and the difference

关 键 词：流行性感冒 儿童 清热灵颗粒 临床观察 

分 类 号：R256.1[医药卫生—中医内科学]