定喘方加减联合西药治疗儿童咳嗽变异性哮喘的疗效及对肺功能、炎症因子的影响  

Efficacy of modified Dingchuan Fang(定喘方)combined with Western medicine in the treatment of cough variant asthma in children and its effects on pulmonary function and inflammatory factors

作　　者：姚利锋[1] 丘颜昭 沈红莲 YAO Lifeng;QIU Yanzhao;SHEN Honglian(Pharmaceutical Preparation Section,Huzhou Hospital of TCM,Huzhou,Zhejiang,313000,China;Department of Pediatrics,Huzhou Hospital of TCM,Huzhou,Zhejiang,313000,China)

机构地区：[1]湖州市中医院药剂科,浙江湖州313000 [2]湖州市中医院儿科,浙江湖州313000

出　　处：《中医儿科杂志》2021年第3期67-71,共5页Journal of Pediatrics of Traditional Chinese Medicine

摘　　要：目的观察定喘方加减联合西药治疗儿童咳嗽变异性哮喘(CVA)的临床疗效及对肺功能、炎症因子的影响。方法选取2018年5月至2020年5月湖州市中医院儿科收治的80例CVA患儿,采用随机数字表法分为治疗组与对照组,各40例,对照组予常规西药治疗,治疗组在对照组治疗方法的基础上给予定喘方加减治疗,2组均1个月为1个疗程,连续治疗2个疗程后统计疗效。结果治疗组的总有效率为90.0%(36/40),显著高于对照组的72.5%(29/40),2组比较,差异有统计学意义(P<0.05)。治疗前,2组肺功能指标呼气峰流速(PEF)25%、PEF50%、PEF75%、第1秒用力呼气容积(FEV1)水平比较,差异均无统计学意义(P>0.05),具有可比性;治疗后,2组肺功能指标PEF25%、PEF50%、PEF75%及FEV1水平均较同组治疗前明显上升,差异均有统计学意义(P<0.05),且治疗组升高更显著(P<0.05)。治疗前,2组咳嗽程度及频率评分比较,差异均无统计学意义(P>0.05),具有可比性;治疗后,2组咳嗽程度及频率评分均较同组治疗前明显降低,差异均有统计学意义(P<0.05),且治疗组降低更显著(P<0.05)。治疗前,2组炎症因子超敏C反应蛋白(hs-CRP)、白细胞介素-17(IL-17)及白细胞介素-23(IL-23)水平比较,差异均无统计学意义(P>0.05),具有可比性;治疗后,2组炎症因子IL-17、IL-23、Hs-CRP水平均较同组治疗前明显降低,差异均有统计学意义(P<0.05),且治疗组降低更显著(P<0.05)。结论定喘方加减联合西药治疗儿童CVA,不仅能明显提高临床疗效,有效缓解临床症状,改善肺功能,而且减轻了炎症反应,值得临床推广应用。Objective To observe the clinical efficacy of modified Dingchuan Fang(定喘方)combined with Western medicine in the treatment of cough variant asthma(CVA)in children and its effects on pulmonary function and inflammatory factors.Methods From May 2018 to May 2020,80 children with CVA admitted into pediatrics department of Huzhou Hospital of TCM were chosen and divided into treatment group and control group according to random number table method,with 40 cases in each group.The control group was given routine Western medicine,on this basis,the treatment group was given modified Dingchuan Fang.The 2 groups were both given 1 month as 1 course of treatment,and we kept statistics about the efficacy after 2 courses of continuous treatment.Results The total effective rate of the treatment group was 90.0%(36/40),which was significantly higher than 72.5%(29/40)of the control group,and the difference was statistically significant between the 2 groups(P<0.05).Before treatment,the difference was not statistically significant in pulmonary function index levels of peak expiratory flow(PEF)25%,PEF50%,PEF75%and forced expiratory volume in one second(FEV1)between the 2 groups(P>0.05),and they were comparable.After treatment,the levels of PEF25%,PEF50%,PEF75%and FEV1 in the 2 groups were significantly higher than those in the same group before treatment,and the difference was statistically significant(P<0.05),and the increase in the treatment group was more significant(P<0.05).Before treatment,the difference of cough degree and frequency scores between the 2 groups was not statistically significant(P>0.05),and they were comparable.After treatment,the cough degree and frequency scores of the 2 groups were significantly lower than those of the same group before treatment,and the difference was statistically significant(P<0.05),moreover,the decrease of the treatment group was more significant(P<0.05).Before treatment,there was no significant difference in the levels of inflammatory factors hypersensitive C-reactive protein(hs-CRP),i

关 键 词：咳嗽变异性哮喘 儿童 定喘方 肺功能 炎症因子 临床观察 

分 类 号：R256.1[医药卫生—中医内科学]