乙型肝炎患者肝炎、肝纤维化时血清HA、LN及Ⅳ-C水平的变化及其意义  

The variationof levels of HA,LN andⅣ-C during the occurrence and hepatic fibrosis period of patients with viral hepatitis and its significance

作　　者：陶运娟 周跃[1] 朱霞峰 TAO Yun-juan(Clinical laboratory,Yancheng hospital of traditional Chinese medicine affiliated to Nanjing University of Traditional Chinese Medicine,Yancheng,Jiangsu,224001,China)

机构地区：[1]南京中医药大学附属盐城市中医院检验科,江苏盐城224001 [2]苏州市相城人民医院检验科,江苏苏州215131

出　　处：《齐齐哈尔医学院学报》2021年第8期678-680,共3页Journal of Qiqihar Medical University

摘　　要：目的探讨乙型肝炎患者的透明质酸(HA)、层粘蛋白(LN)及Ⅳ型胶原蛋白(Ⅳ-C)水平,并分析其与疾病严重程度的相关性。方法选择2019年1月—2020年6月本院收治的103例乙型肝炎患者为研究对象,根据是否合并肝纤维化分为单纯肝炎组(75例)和合并肝纤维化组(28例)两组;同时选取同期在本院体检的48名健康体检者作为对照组。观察对照组、单纯肝炎组和合并肝纤维化组患者的HA、LN、Ⅳ-C、谷丙转氨酶(ALT)、谷草转氨酶(AST)、总胆红素(TBIL)的差异,分析乙型肝炎患者HA、LN、Ⅳ-C水平与肝功能指标的相关性。结果合并肝纤维化组HA、LN及Ⅳ-C水平高于单纯肝炎组和对照组,单纯肝炎组HA、LN水平高于对照组,差异均有统计学意义(P<0.05)。单纯肝炎组Ⅳ-C水平与对照组比较,差异无统计学意义(P>0.05)。三组研究对象的ALT、AST、TBIL水平由高到低分别为合并肝纤维化组、单纯肝炎组和对照组,差异均有统计学意义(P<0.05);乙型肝炎患者的HA、LN和Ⅳ-C水平与ALT、AST和TBil水平正相关,差异均有统计学意义(均P<0.05)。结论乙型肝炎患者的HA、LN和Ⅳ-C较高,与患者的肝功能指标正相关,且合并肝纤维化的患者HA、LN和Ⅳ-C更高。Objective To observe the levels of hyaluronic acid(HA),laminin(LN)and typeⅣcollagen(Ⅳ-C)in patients with viral hepatitis and to analyze their correlation with the severity of the disease.Methods The patients with hepatitis B treated in our hospital from January 2019 to June 2020 were selected as the subjects.According to whether they were combined with liver fibrosis,they were divided into simple hepatitis group and liver fibrosis group.At the same time,48 health people received health check-up in our hospital was selected as the control group.To observe the difference of HA,LN,Ⅳ-C,alanine transaminase(ALT),aspartate aminotransferase(AST),total bilirubin(TBIL)among the control group,simple hepatitis group and liver fibrosis group,and to analyze the correlation between HA,LN,Ⅳ-C level and liver function index of hepatitis B patients.Results The HA,LN,andⅣ-C levels in the liver fibrosis group was higher than that in the hepatitis group and the control group;the HA and LN levels of simple hepatitis group was higher than that of control group,all the differences were statistically significant(P<0.05).The difference between the simple hepatitis group and control group inⅣ-C level was not statistically significant(P>0.05).The ALT,AST,and TBIL levels of the three groups were liver fibrosis group,hepatitis alone group and control group from the highest to the lowest,differences were statistically significant(P<0.05).The HA,LN,Ⅳ-C in hepatitis B patients were positively correlated with ALT,AST,and TBIL levels(P<0.05).Conclusions HA,LN andⅣ-C in patients with viral hepatitis are relatively high,and they are positively correlated with liver function indexes,and patients with fiber cirrhosis have higher HA,LN andⅣ-C levels.

关 键 词：乙型肝炎 透明质酸 层粘蛋白 Ⅳ型胶原蛋白 

分 类 号：R512.6[医药卫生—内科学]