轮状病毒颗粒样候选疫苗研究现状和展望  

Status and prospects of rotavirus particle-like vaccines

作　　者：杜加亮[1] 刘艳[1] Du Jialiang;Liu Yan(Division of Enteroviral Vaccines,National Institutes for Food and Drug Control,Beijing 102629,China)

机构地区：[1]中国食品药品检定研究院肠道病毒疫苗室,北京102629

出　　处：《中华微生物学和免疫学杂志》2021年第5期388-394,共7页Chinese Journal of Microbiology and Immunology

基　　金：国家科技重大专项(2012ZX10004702)。

摘　　要：人轮状病毒(rotavirus,RV)是引发全球性人类非细菌性急性胃肠炎疾病的主要病原体之一,减毒活疫苗是预防RV感染的有效手段。为了提高RV疫苗的安全性,开发活病毒疫苗以外的其他形式疫苗,如灭活疫苗、亚单位疫苗、病毒样颗粒(virus like particle,VLP)等,以避免减毒疫苗株通过回复突变恢复毒力、导致严重不良反应(如肠套叠)或造成环境污染,本文就RV VLP疫苗的研究进行综述和展望。Human rotavirus(RV)is one of the main pathogens that cause non-bacterial acute gastroenteritis diseases globally.Live attenuated vaccine is an effective method to prevent RV infection.In order to improve the safety of RV vaccines,it is a good choice to develop other forms of vaccines other than live virus vaccines to avoid attenuated vaccine strains to restore virulence through back mutation or cause environmental contamination.This article reviews the research of RV virus like particle(VLP)vaccines.

关 键 词：轮状病毒 病毒样颗粒 疫苗 

分 类 号：R392-33[医药卫生—免疫学]