卡维地洛对无心肌梗死冠心病心绞痛患者心功能及心肌损伤的影响  

Effect of Carvedilol on Cardiac Function and Myocardial Injury in Non-Myocardial Infarction Patients with Coronary Heart Disease and Angina Pectoris

作　　者：于秀清[1] 李春艳 尹春风[1] 姜芊竹[3] YU Xiuqing;LI Chunyan;YIN Chunfeng;JIANG Qianzhu(Zunhua People’s Hospital,Tangshan,Hebei,China 064200;Yutian County Hospital,Tangshan,Hebei,China 064100;The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin,Heilongjiang,China 150001)

机构地区：[1]河北省遵化市人民医院,河北唐山064200 [2]河北省玉田县医院,河北唐山064100 [3]黑龙江中医药大学附属第二医院,黑龙江哈尔滨150001

出　　处：《中国药业》2021年第12期79-81,共3页China Pharmaceuticals

基　　金：河北省医学科学研究重点课题[20191739]。

摘　　要：目的探讨卡维地洛对无心肌梗死冠状动脉粥样硬化性心脏病(简称冠心病)心绞痛患者心功能及心肌损伤的影响。方法选取河北省遵化市人民医院2014年1月至2017年5月收治的无心肌梗死冠心病心绞痛患者120例,按随机数字表法分为研究组和对照组,各60例。两组患者均予常规药物治疗,研究组患者加服卡维地洛片,均连续治疗3个月。结果研究组中途自愿退出1例、失访2例,对照组失访1例、临床评估数据缺失1例,予以剔除。研究组总有效率为91.23%,明显高于对照组的77.59%(P<0.05);治疗后,研究组患者心绞痛的发生频率及疼痛数字评分,QT间期离散度及心肌肌钙蛋白T、肌酸激酶同工酶、髓过氧化物酶水平均明显低于对照组,左室收缩末期内径、左室舒张末期内径均明显短于对照组,6 min步行距离明显长于对照组(P<0.05),左室射血分数明显高于对照组(P<0.05);治疗期间研究组与对照组不良反应发生率相当(15.79%比10.34%,P>0.05)。结论在常规药物治疗基础上加用卡维地洛治疗无心肌梗死冠心病心绞痛有一定效果,能降低患者心绞痛发作频率和疼痛程度,改善心功能、心肌损伤指标及预后。Objective To investigate the effect of carvedilol on cardiac function and myocardial injury in non-myocardial infarction patients with coronary heart disease and angina pectoris.Methods A total of 120 non-myocardial infarction patients with coronary heart disease and angina pectoris admitted to the Zunhua People’s Hospital from January 2014 to May 2017 were selected and divided into the study group and the control group according to the random number table method,60 cases in each group.The patients in the two groups were treated with conventional drugs,on this basis,the patients in the study group were treated with Carvedilol Tablets.Both groups were continuously treated for three months.Results In the study group,one case voluntarily dropped out and two cases were lost to follow-up.In the control group,one case was lost to follow-up and one case was missing clinical evaluation data.The clinical data of the above patients were excluded.The total effective rate of the study group was 91.23%,which was significantly higher than77.59%of the control group(P<0.05).After treatment,the frequency of angina pectoris,numeric rating scales(NRS)score,QT interval dispersion(QTd),levels of cardiac troponin T(cTnT),creatine kinase-MB(CK-MB)and myeloperoxidase(MPO)in the study group were significantly lower than those in the control group,the left ventricular end-systolic diameter(LVESd)and left ventricular end-diastolic diameter(LVEDd)in the study group were significantly shorter than those in the control group,and the 6-minute walking distance(6 MWD)in the study group was significantly longer than that in the control group,and the left ventricular ejection fraction(LVEF)in the study group was significantly higher than that in the control group(P<0.05).During the treatment,the incidence of adverse reactions in the study group was similar to that in the control group(15.79%vs.10.34%,P>0.05).Conclusion On the basis of conventional drug therapy,carvedilol has a certain effect in the treatment of non-myocardial infarction patients

关 键 词：冠状动脉粥样硬化性心脏病 心绞痛 卡维地洛 临床疗效 心功能 心肌损伤 

分 类 号：R969.4[医药卫生—药理学] R972[医药卫生—药学]