核质转运异常与神经退行性疾病  

Nucleocytoplasmic transport and neurodegenerative diseases

作　　者：王子见 李子恒 常亦昆 张甜 任媛媛 何凤琴[1] WANG Zi-jian;LI Zi-heng;CHANG Yi-kun;ZHANG Tian;REN Yuan-yuan;HE Feng-qin(Key Laboratory of Natural Product Development and Anticancer Innovative Drug Research in Qinling,Xi'an University,Xi'an 710065,China;College of Medicine,Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]西安文理学院,西安市秦岭天然产物开发与创新药物研究重点实验室,陕西西安710065 [2]郑州大学医学院,河南郑州450052

出　　处：《药学学报》2021年第5期1217-1228,共12页Acta Pharmaceutica Sinica

基　　金：陕西省自然科学基础研究计划资助项目(2020JM-620);西安市科技计划创新基金“文理专项”项目(2020KJWL04);西安文理学院博士启动金(06005026);国家级大学生创新创业项目(S202011080012,201911080013);省级大学生创新创业项目(S202011080058)。

摘　　要：核质转运过程作为真核细胞的基本生命活动之一,对细胞生理和病理过程都至关重要。大量证据表明,核质转运异常是神经退行性疾病的关键致病因素,而核质转运障碍的调控机制对于阐明神经退行性疾病的发病机制和干预治疗至关重要。本文搜集20年来核质转运异常在神经退行性疾病发病机制中的相关研究,综述在肌萎缩脊髓侧索硬化症/前额颞叶痴呆、亨廷顿舞蹈症和脊髓小脑共济失调等神经退行性疾病中的核质转运现象和涉及的调控机制,进一步探讨在目前研究中存在的问题并提出建议,为神经退行性疾病的致病机制和药物靶标研究提供理论依据。Nucleocytoplasmic transport is the basic cellular activity of eukaryotic cells,which plays a role in cell physiological and pathological processes.A large amount of evidences indicate that impaired nucleocytoplasmic trafficking has emerged as a mechanism contributing to the pathology of neurodegenerative diseases.The regulation of nucleocytoplasmic transport is crucial to elucidate the pathogenesis and intervention in the neurodegenerative diseases.This article summarizes the evidences in disturbed nucleocytoplasmic transport of neurodegenerative diseases in the past two decades,further explores the directions and provides a theoretical basis for the pathogenesis and drug targets in neurodegenerative diseases.

关 键 词：核质转运 神经退行性疾病 致病机制 药物靶标 

分 类 号：R964[医药卫生—药理学]