藏药甘青乌头中1个新的双二萜生物碱  

A novel dimeric diterpenoid alkaloid from the Tibetan medicinal plant Aconitum tanguticum(Maxim.)Stapf

作　　者：杨丽华[1,2] 王月 刘晓谦 梁曜华[1] 李春[1] 王智民[1] YANG Li-hua;WANG Yue;LIU Xiao-qian;LIANG Yao-hua;LI Chun;WANG Zhi-min(Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China;Hunan University of Science and Engineering,Yongzhou 425199,China;Guangdong Pharmaceutical University,Guangzhou 510006,China)

机构地区：[1]中国中医科学院中药研究所,北京100700 [2]湖南科技学院,湖南永州425199 [3]广东药科大学,广东广州510006

出　　处：《药学学报》2021年第5期1429-1433,共5页Acta Pharmaceutica Sinica

基　　金：北京市自然科学基金项目(7132152);中央级公益性科研院所基本科研业务费专项资金资助项目(ZXKT17039)。

摘　　要：从甘青乌头全草中分得两个双二萜生物碱,经1D,2D-NMR及HR-MS数据解析确定了它们的结构,其中1个为新化合物,命名为tanguticurine A(1),另1个为已知化合物anthoroidine B(2),二者均为首次从甘青乌头中分离得到。抗病毒实验结果显示化合物1对HCV和EV71均有较好的抑制作用,半数有效浓度(EC_(50))分别为15.5和9.7μmol·L~(-1),并显示较低的细胞毒性。因此,化合物1是一个较好的抗病毒先导化合物,值得深入研究。Two dimeric diterpenoid alkaloids were isolated from the whole plant of Aconitum tanguticum(Maxim.)Stapf and their structures were elucidated by extensive analysis of 1 D,2 D-NMR and HR-MS data.One is a new compound and named tanguticurine A(1),and the other is the known compound anthoroidine B(2);both were isolated from this plant for the first time.The antiviral activity of compounds 1 and 2 against HCV and EV71 were also evaluated.It was found that compound 1 had a good inhibitory effect on HCV and EV71 with EC50 values of 15.5 and 9.7μmol·L-1,respectively,and showed low cytotoxicity.Therefore,compound 1 is a good antiviral lead compound and deserves further study.

关 键 词：甘青乌头 二萜生物碱 结构鉴定 抗病毒活性 

分 类 号：R284[医药卫生—中药学]