中国10个地区成年人骨折住院率的描述性分析  

Descriptive analysis of fracture hospitalization rate in adults from 10 regions of China

作　　者：申泽薇 魏玉虾 余灿清[1] 郭彧[2] 卞铮[2] 裴培[2] 陈君石 陈铮鸣[4] 吕筠[1] 李立明[1] 中国慢性病前瞻性研究项目协作组 Shen Zewei;Wei Yuxia;Yu Canqing;Guo Yu;Bian Zheng;Pei Pei;Chen Junshi;Chen Zhengming;Lyu Jun;Li Liming;China Kadoorie Biobank Collaborative Group(Department of Epidemiology and Biostatistics,School of Public Health,Peking University/Peking University Center for Public Health and Epidemic Preparedness&Response/Peking University Key Laboratory of Molecular Cardiovascular Sciences,Ministry of Education,Beijing 100191,China;Chinese Academy of Medical Sciences,Beijing 100730,China;China National Center for Food Safety Risk Assessment,Beijing 100022,China;Clinical Trial Service Unit and Epidemiological Studies Unit,Nuffield Department of Population Health,University of Oxford,Oxford OX37LF,UK;不详)

机构地区：[1]北京大学公共卫生学院流行病与卫生统计学系/北京大学公众健康与重大疫情防控战略研究中心/北京大学分子心血管学教育部重点实验室,100191 [2]中国医学科学院,北京100730 [3]国家食品安全风险评估中心,北京100022 [4]英国牛津大学临床与流行病学研究中心纳菲尔德人群健康系,OX37LF [5]不详

出　　处：《中华流行病学杂志》2021年第5期771-779,共9页Chinese Journal of Epidemiology

基　　金：国家自然科学基金(81941018);中国香港KadoorieCharitable基金;英国WellcomeTrust(212946/Z/18/Z,202922/Z/16/Z,104085/Z/14/Z,088158/Z/09/Z)。

摘　　要：目的:分析骨折住院率的三间分布。方法:纳入参与中国慢性病前瞻性研究基线调查者,剔除2009年以前失访或死亡者,共纳入506004人。采用负二项回归模型分析2009-2016年10个项目地区任意骨折和5个部位骨折(上肢、下肢、椎骨、骨盆和髋部骨折)住院率的时间、地区和人群分布特征。结果:在(7.7±1.2)年(累积3899814人年)的随访期间,共记录到17118例任意骨折住院事件,任意骨折的粗住院率为4.39/1000人年。在控制了固定队列人群年龄增长后,2009-2016年间,不同部位的骨折住院率均呈上升趋势,任意骨折年增长率(95%CI)为9.1%(8.3%~9.9%)。除髋部骨折外,农村骨折住院率高于城市(P<0.05),农村和城市的任意骨折住院率分别为5.42/1000人年和3.24/1000人年。骨折住院率随年龄增加。<50岁时,除骨盆骨折外,男性骨折住院率高于女性;≥50岁时,女性骨折住院率均高于男性。结论:骨折住院率随年龄增加的同时,也表现出长期增长趋势。我国正在迈入老龄化社会,骨折的疾病负担将会越来越重,预防骨质疏松和防止伤害相关骨折的发生,从而减少骨折发病率具有重要意义。Objective To analyze the epidemiological distributions of fracture hospitalization.Methods The present study included participants who participated in the baseline survey of China Kadoorie Biobank(CKB)and excluded participants who were lost to follow up or died before 2009,leaving a total of 506004 participants.Negative binomial regression models were used to analyze the epidemiological distribution of any fracture and fracture at five specific body sites(upperlimb,lowerlimb,spine,pelvis and hip)from 2009 to 2016 in 10 regions.Results During a median follow-up of(7.7±1.2)years(total person-years 3899814),we documented 17118 cases of fracture hospitalizations.The crude fracture hospitalization rate was 4.39/1000 person-years.After controlling for the increasing age of the fixed cohort,the hospitalization rates of fractures at various body sites increased from 2009 to 2016,with an annual growth rate(95%CI)of 9.1%(8.3%-9.9%)for any fracture.The fracture hospitalization rate was higher in rural than in urban areas except for hip fractures(P<0.05)and the hospitalization rate of any fracture were 5.42/1000 and 3.24/1000 person-years in rural and urban areas,respectively.Fracture hospitalization rate increased by age.In participants aged<50 years,men had higher fracture hospitalization rates than women except for pelvis fracture,while in those aged≥50 years,women had higher fracture hospitalization rates than men.Conclusions Fracture hospitalization rates increased by age and also showed upward selular trends.As China has begun the aging process,fractures impose a heavier burden on society.It is of great significance to prevent osteoporosis-related and injury-related fractures in order to reduce fractures incidence.

关 键 词：骨折住院率 三间分布 队列研究 

分 类 号：R683[医药卫生—骨科学]