外周血红细胞平均分布宽度与前列腺癌的相关性研究  

Correlation between red cell distribution width and prostate cancer

作　　者：黄晓峰 范雪明 姚天悦 袁文华[1] 赵智赟[1] 宋云霄[1] HUANG Xiaofeng;FAN Xueming;YAO Tianyue;YUAN Wenhua;ZHAO Zhiyun;SONG Yunxiao(Department of Clinical Laboratory,Xuhui Central Hospital,Shanghai 200031,China;Shanghai Baoshan Yuepu Shengqiao Community Health Service Center,Shanghai 201900,China)

机构地区：[1]上海市徐汇区中心医院检验科,上海200031 [2]上海市宝山区月浦镇盛桥社区卫生服务中心,上海201900

出　　处：《检验医学》2021年第6期590-595,共6页Laboratory Medicine

摘　　要：目的测定前列腺癌患者外周血红细胞平均分布宽度(RDW)水平,分析RDW与前列腺癌的相关性。方法选取2016年1月1日—2020年6月1日上海市徐汇区中心医院497例前列腺癌患者(前列腺癌组),以同期519名健康体检者作为对照组。队列研究:对2016年1月1日—2017年6月30日就诊的100例前列腺癌患者进行3年的随访,有88例患者完成随访,并进行了详细的体格检查和血液学检查。比较所有研究对象年龄、体质量、糖尿病、高血压、吸烟史、饮酒史等资料。测定所有研究对象RDW水平,并对其与前列腺癌的相关性进行分析。根据研究对象年龄分为<60岁、60~69岁、70~79岁、≥80岁4个年龄组,比较各年龄组RDW水平。结果前列腺癌组RDW水平显著高于对照组(P<0.001)。不同年龄组前列腺癌患者RDW水平显著高于对照组(P<0.001)。多因素二分类Logistic回归分析结果显示,RDW升高[比值比(OR)=3.300,95%可信区间(CI)为2.290~4.753,P<0.001]、体质量指数升高(OR=1.086,95%CI为1.003~1.177,P=0.042)、t-PSA升高(OR=1.255,95%CI为1.198~1.315,P<0.001)是前列腺癌发生的危险因素。基线高RDW水平[风险比(HR)=7.439,95%CI为4.278~21.088,P<0.001)为前列腺癌患者3年总生存率的危险因素。结论前列腺癌患者RDW水平显著升高,且是前列腺癌发生和预后的危险因素。Objective To determine the level of red cell distribution width(RDW)in peripheral blood of patients with prostate cancer,and to investigate the correlation between RDW and prostate cancer.Methods Totally,497 patients diagnosed with prostate cancer in Xuhui Central Hospital from January 1,2016 to June 1,2020 were enrolled,and 519 healthy subjects in the same period were enrolled as control group.A total of 100 patients with prostate cancer from January 1,2016 and June 30,2017 were enrolled and followed up for 3 years.Detailed physical examination and blood examination results of 88 patients were collected.The data,such as age,weight,diabetes mellitus,hypertension,smoking history and alcohol consumption history,were collected.RDW levels were determined.The correlation between RDW and prostate cancer was evaluated.The subjects were further classified into 4 subgroups(<60,60-69,70-79 and>80 years old)according to ages.Their RDW levels were compared.Results Compared with control group,RDW level in prostate cancer group was higher than that in control group(P<0.001).In the age subgroups,the RDW level in prostate cancer group was increased compared with that in control group(P<0.001).Multivariate binary Logistic regression analysis found that RDW increased[odds ratio(OR)=3.300,95%confidence interval(CI)2.290-4.753,P<0.001,body mass index increased(OR=1.086,95%CI 1.003-1.177,P=0.042)and t-PSA increased(OR=1.255,95%CI 1.198-1.315,P<0.001)were risk factors for prostate cancer.Increased RDW was also a risk factor for prostate cancer in different age subgroups.High RDW level at baseline[hazard ratio(HR)=7.439,95%CI 4.278-21.088,P<0.001]was a risk factor for 3-year overall survival in prostate cancer patients.Conclusions The level of RDW is increased in patients with prostate cancer,which is a risk factor for the development and prognosis of prostate cancer.

关 键 词：红细胞平均分布宽度 前列腺癌 危险因素 标志物 预后 

分 类 号：R446.1[医药卫生—诊断学]