标准物质在临床质谱技术中的应用  

The application of certified reference materials for clinical mass spectrometry

作　　者：沈凌晓 马金飞 杨青青 刘鹏云 刘华芬 Shen Lingxiao;Ma Jinfei;Yang Qingqing;Liu Pengyun;Liu Huafen(Hangzhou Calibra Diagnostics Co.,LTD.,Hangzhou 310000,China)

机构地区：[1]杭州凯莱谱精准医疗检测技术有限公司,杭州310000

出　　处：《中华检验医学杂志》2021年第5期437-441,共5页Chinese Journal of Laboratory Medicine

摘　　要：标准物质是实现检验结果准确可比的主要技术手段之一,而质谱技术作为一种临床检验新技术,在使用标准物质时同样需要区分标准物质的不同作用,合理选择并应用于测量方法确认、校准及质量控制等方面,从而保证检验结果的准确性和可比性。本文从标准物质在临床质谱中存在的问题出发,对于标准物质在测量方法确认、校准物及质量控制等方面的使用注意事项进行了介绍和总结。Reference materials are one of the major approaches to achieve measurement accuracy and metrological comparability.Different functions of reference materials should also be distinguished when applied to mass spectrometry as an emerging technology in clinical laboratory.Proper reference materials for validation,calibration and quality control of measurement method can ensure the accuracy and comparability of test results.Based on the problems of reference materials in clinical mass spectrometry,the precautions for the use of reference materials are summarized in the aspects of measurement method validation,calibrator usage and quality control.

关 键 词：标准物质 临床质谱技术 应用 

分 类 号：R446[医药卫生—诊断学]