Design, Synthesis and Biological Activity of N-Sulfonyl Aromatic Amide Derivatives  

作　　者：LIU Wen-Rui HUA Xue-Wen ZHOU Sha YUAN Feng-Ying WANG Gui-Qing LIU Yi XING Xiao-Ran 刘汶芮;华学文;周沙;袁凤英;王桂清;刘艺;邢晓冉(College of Agriculture,Liaocheng University,Liaocheng 252000,China;Collaborative Innovation Center of Zhejiang Province for Green Pesticide,School of Forestry and Bio-technology,Zhejiang A&F University,Hangzhou 311300,China;Liaocheng Center for Disease Control and Prevention,Liaocheng 252000,China)

机构地区：[1]College of Agriculture,Liaocheng University,Liaocheng 252000,China [2]Collaborative Innovation Center of Zhejiang Province for Green Pesticide,School of Forestry and Bio-technology,Zhejiang A&F University,Hangzhou 311300,China [3]Liaocheng Center for Disease Control and Prevention,Liaocheng 252000,China

出　　处：《Chinese Journal of Structural Chemistry》2021年第5期666-674,531,共10页结构化学（英文）

基　　金：supported by the National Natural Science Foundation of China(32001929);the Natural Science Foundation of Shandong Province(ZR2017BC053);the Innovation and Entrepreneurship Training Program for College Students of Liaocheng University(CXCY2020Y116)。

摘　　要：Fifteen novel N-sulfonyl aromatic amide derivatives were designed and synthesized, and the structures were characterized by 1H-and 13C-NMR, EA and HRMS. The crystal structures of compounds I-8 and I-9 were obtained from X-ray diffraction: I-8 is of triclinic system, Mr = 372.35, space group P2_(1/n) with a = 7.9151(10), b = 8.5637(11), c = 12.2022(15) A, β = 86.865(2)o, V = 807.09(18) A^(3), Z = 2, F(000) = 384, D_(c) = 1.532 g/cm^(3), the final R = 0.0408 and wR = 0.1068 for 2836 unique reflections with 2435 observed ones(I > 2σ(I)). I-9 belongs to triclinic system, M_r = 407.39, space group P2_1/n, with a = 8.4911(8), b = 8.6053(9), c = 14.5808(15) A, β = 77.1190(10)o, V = 995.44(17)A^(3), Z = 2, F(000) = 416, D_(c) = 1.359 g/cm^(3), the final R = 0.0567 and wR = 0.1779 for 3475 unique reflections with 2392 observed ones(I > 2σ(I)). The preliminary bioassay results indicated that the target compounds showed weak nematicidal activity, while compound I-5 displayed good fungicidal activity against Colletotrichum capsici with the inhibition rate of 61.7%.

关 键 词：heterocyclic amide SYNTHESIS crystal structure fungicidal activity nematicidal activity 

分 类 号：TQ450.1[化学工程—农药化工]