Syntheses, Structures and Anticancer Activities of Two Tri(o-halobenzyl)tin Substituted Benzoates  

作　　者：TAN Xu-Liang ZHANG Fu-Xing HE Li-Fang GUI Shi-Yin ZHANG Yi-Ling ZHU Xiao-Ming SHENG Liang-Bing FENG Yong-Lan YU Jiang-Xi JIANG Wu-Jiu 谭许亮;张复兴;何丽芳;桂诗音;张艺龄;朱小明;盛良兵;冯泳兰;庾江喜;蒋伍玖(Department of Chemistry and Materials Science,Hengyang Normal University,Key Laboratory of Functional Metal-organic Complexes of Hunan Province,Key Laboratory of Functional Organometallic Materials of Colleges of Hunan Province,Hengyang,Hunan 421008,China)

机构地区：[1]Department of Chemistry and Materials Science,Hengyang Normal University,Key Laboratory of Functional Metal-organic Complexes of Hunan Province,Key Laboratory of Functional Organometallic Materials of Colleges of Hunan Province,Hengyang,Hunan 421008,China

出　　处：《Chinese Journal of Structural Chemistry》2021年第5期675-681,531,共8页结构化学（英文）

基　　金：supported by the open fund project of Hunan Provincial innovation platform(18K089);the key project of Hunan Provincial education department(19A070);the open fund of Hunan Provincial key laboratory(M018K07);Hengyang science and technology plan project,Hunan Provincial applied characteristic discipline fund;Hunan Provincial science and technology innovation team support plan。

摘　　要：Tri(o-chlorobenzyl)tin 2,4,6-trimethylbenzoate(1) and tri(o-bromobenzyl)tin salicylate(2) were synthesized and characterized by elemental analysis, IR spectroscopy, NMR(1H, 13C and 119Sn), thermogravimetric analysis, and single-crystal X-ray diffraction. The initio calculation and in vitro anticancer activity test were performed for compounds 1 and 2. They are both single tin nucleus structures and the tin atoms were tetracoordinated in a distorted tetrahedral configuration;Compounds 1 and 2 showed stronger anticancer activity than cisplatin in human cervical cancer cells(Hela), liver cancer cells(Hu H-7), non-small cell lung cancer cells(A549), lung adenocarcinoma cells(H1975) and breast cancer(MCF-7).

关 键 词：tri(o-chlorobenzyl)tin 2 4 6-trimethylbenzoate tri(o-bromobenzyl)tin salicylate crystal structure quantum chemistry in vitro antitumor activity 

分 类 号：TQ460.1[化学工程—制药化工]