TG/HDL-c与职业人群ASCVD风险的相关性分析  

Analysis on correlation between TG/HDL-c and ASCVD risk in occupational population

作　　者：刘玲娇[1] 林燕[1] 余湘尤 闫妮 LIU Lingjiao;LIN Yan;YU Xiangyou;YAN Ni(Department of Endocrinology and Metabolism,Shaanxi Provincial People′s Hospital,Xi′an,Shaanxi 710001,China)

机构地区：[1]陕西省人民医院内分泌代谢科,西安710068

出　　处：《重庆医学》2021年第11期1891-1895,共5页Chongqing medicine

摘　　要：目的了解三酰甘油(TG)/高密度脂蛋白胆固醇(HDL-c)与职业人群动脉粥样硬化性心血管疾病(ASCVD)风险的相关性。方法对8806例职业人群进行ASCVD风险评估,比较低危、中危和高危组传统危险因素及TG、HDL-c水平的差异,分析其与ASCVD风险的相关性,探讨其对ASCVD风险的预测价值。结果共纳入8806例参加体检的职业人群,根据ASCVD风险评估结果分为低危组6844例、中危组1133例、高危组829例;男性ASCVD风险低危、中危及高危比例分别为77.0%、13.2%、9.8%,女性分别为80.8%、11.5%、7.6%,男性ASCVD风险整体高于女性;男性组及女性组ASCVD风险均随着年龄的增大而增加,同一年龄层内男性ASCVD风险高于女性,差异有统计学意义(P<0.05)。人群年龄、吸烟、饮酒、合并高血压及糖尿病比例、收缩压(SBP)、舒张压(DBP)、TG、总胆固醇(TC)、非HDL-c、TG/HDL-c、空腹血糖(FBG)均随着ASCVD风险增加而增加(P<0.05);人群平均体重指数(BMI)、LDL-c、同型半胱氨酸(Hcy)和尿酸(UA)水平均是ASCVD低危组最低,中危组最高(均P<0.05);人群合并非酒精性脂肪肝(NAFLD)的比例在三组间差异无统计学意义(P>0.05)。多元logistic回归分析结果显示,校正混杂因素性别、年龄、吸烟、饮酒、BMI、SBP、LDL-c、TC、FBG后,TG/HDL-c与ASCVD风险仍独立相关,与低危组相比,中危组TG/HDL-c的OR值为1.51(95%CI:1.429~1.607),高危组TG/HDL-c的OR值为1.651(95%CI:1.535~1.775)。受试者工作特征(ROC)曲线显示,TG/HDL-c对ASCVD风险具有一定预测价值,且高于传统的危险因素LDL-c和TC(ROC曲线下面积0.717 vs.0.649,0.704)。结论TG/HDL-c是职业人群ASCVD风险的独立危险因素,对ASCVD风险具有一定预测价值。Objective To understand the correlation between TG/HDL-c and atherosclerotic cardiovascular disease(ASCVD)risk in the occupational population.Methods The risk assessment of ASCVD was carried out in 8806 cases of occupational group.The differences of traditional risk factors and the levels of TG and HDL-c were compared among the low,medium and high risk groups.Their correlation with the ASCVD risk was analyzed,and its predictive value for risk of ASCVD was discussed.Results A total of 8806 occupational populations participating in the physical examination were included.According to the risk assessment results of ASCVD,they were divided into 6844 cases in the low risk group,1133 cases in the medium risk group and 829 cases in the high risk group.The risk rates of ASCVD in males were 77.0%in low risk,13.2%in middle risk and 9.8%in high risk respectively,and those in females were 80.8%,11.5%and 7.6%respectively.The risk of ASCVD in males was higher than that in females.The risk of ASCVD was increased with the increase of age in both male and female groups.The risk of ASCVD in male was higher than that in femalein the same age group,and the difference was statistically significant(P<0.05).Age,smoking,drinking,hypertension and diabetes,SBP,DBP,TG,TC,non HDL-c,TG/HDL and FBG all were increased with the ASCVD risk increase(P<0.05);the average BMI,LDL-c,Hcy and UA were the lowest in the low-risk group,and the highest in the middle-risk group(P<0.05);the proportion of complicating NAFLD had no statistically significant difference among the three groups(P>0.05).The multivariate logistic regression analysis results showed that TG/HDL-c was still independently correlated with ASCVD risk after adjusting the confounding factors such as gender,age,smoking,drinking,BMI,SBP,LDL-c,TC and FBG.Compared with the low-risk group,the OR value of TG/HDL-c in the moderate-risk group was 1.51(95%CI:1.429-1.607),which in the high-risk group was 1.651(95%CI:1.535-1.775).The receiver operating characteristic(ROC)curve showed that TG/HDL-c had

关 键 词：职业人群 动脉粥样硬化性心血管疾病 风险评估 三酰甘油/高密度脂蛋白胆固醇 

分 类 号：R587.1[医药卫生—内分泌]