血脂、血尿酸对上尿路结石最大径及数目的影响  

Effect of blood lipid and blood uric acid on maximal diameter and number of upper urinary calculi

作　　者：肖莉 汪财霞 张小马 XIAO Li;WANG Caixia;ZHANG Xiaoma(Health Management Center,Fourth Affiliated Hospital of Anhui Medical University,Hefei,Anhui 230012,China;Department of Urologic Surgery,Fourth Affiliated Hospital of Anhui Medical University,Hefei,Anhui 230012,China)

机构地区：[1]安徽医科大学第四附属医院健康管理中心,合肥230012 [2]安徽医科大学第四附属医院泌尿外科,合肥230012

出　　处：《重庆医学》2021年第11期1899-1904,共6页Chongqing medicine

摘　　要：目的探讨血脂、血尿酸水平对不同性别人群上尿路结石大小及数目的影响,为健康人群上尿路结石的预防提供一定的参考。方法回顾性分析2017年2月至2018年2月该院住院的144例上尿路结石患者的临床资料,比较血脂、血尿酸异常代谢水平与正常代谢水平结石最大径及数目,并分析血脂、血尿酸水平与结石最大径及数目的关系。结果男性高低密度脂蛋白-胆固醇(LDL-c)患者结石最大径明显大于正常LDL-c者[(1.94±1.01)cm vs.(1.54±0.88)cm,P<0.05]。男性结石最大径与三酰甘油、LDL-c、血尿酸水平呈正相关,女性结石最大径与血尿酸水平呈正相关(P<0.05)。多因素线性回归分析显示,LDL-c、血尿酸是男性结石最大径的独立影响因素,血尿酸是女性结石最大径的独立影响因素(P<0.05)。多因素logistic分析显示,血脂、血尿酸水平对结石数目无影响。结论血脂、血尿酸对上尿路结石大小有一定影响,并存在性别差异。血尿酸水平可能是不同性别上尿路结石大小的共同影响因素,但对结石数目无影响。Objective To explore the effects of blood lipid and blood uric acid levels on the size and number of upper urinary calculi in different sexes of population in order to provide some reference for the prevention of upper urinary calculi in healthy people.Methods The clinical data of 144 inpatients with upper urinary calculi in this hospital from February 2017 to February 2018 were retrospectively analyzed.The abnormal metabolic levels and normal metabolic levels of blood lipid and uric acid,maximum diameter and number of stones and compared.The relationship between blood lipid and blood uric acid levels with the maximal diameter and number of calculi was analyzed.Results The maximum diameter of stones in the male patients with high low-density lipoprotein-cholesterol(LDL-c)was significantly larger than that in the male patients with normal LDL-c level[(1.94±1.01)cm vs.(1.54±0.88)cm,P<0.05].The maximum diameter of stones in male was positively correlated with triacylglycerol,LDL-c and blood uric acid,the maximum diameter of stones in female was positively correlated with blood uric acid(P<0.05).The multivariate linear regression analysis showed that LDL-c and blood uric acid were the independent influencing factors of the stone maximum diameter in male,and blood uric acid was the independent influencing factor of the stone maximum diameter in female(P<0.05).The multivariate logistic analysis showed that the levels of blood lipid and blood uric acid had no effect on the number of stones.Conclusion The levels of blood lipid and blood uric acid have a certain influence on the size of upper urinary calculi,and the sexual difference exists.Blood uric acid level may be a common factor of the size of upper urinary tract calculi in different sexes,but which have no effect on the number of stones.

关 键 词：上尿路结石 脂蛋白类 尿酸 性别因素 

分 类 号：R692.4[医药卫生—泌尿科学]