Current researches on design and manufacture of biopolymer-based osteochondral biomimetic scaffolds  

作　　者：Yanen Wang Ying Guo Qinghua Wei Xinpei Li Kang Ji Kun Zhang 

机构地区：[1]Department of Mechanical and Electronic Engineering,School of Mechanical Engineering,Northwestern Polytechnical University,Xi’an 710072,China [2]Institute of Medical Research,Northwestern Polytechnical University,Xi’an 710072,China

出　　处：《Bio-Design and Manufacturing》2021年第3期541-567,共27页生物设计与制造（英文）

基　　金：Funding was supported by the Key Research and Development Program of Shaanxi Province(Grant No.2020ZDLSF04-07);the National Key Research and Development Program of China(Grant No.2019QY(Y)0502);the National Natural Science Foundation of China(Grant No.51905438);the Innovation Platform of Biofabrication(Grant No.17SF0002);the Fundamental Research Funds for the Central Universities(Grant No.31020190502009).

摘　　要：Currently,osteochondral(OC)tissue engineering has become a potential treatment strategy in repairing chondral lesions and early osteoarthritis due to the limited self-healing ability of cartilage.However,it is still challenging to ensure the integrity,physiological function and regeneration ability of stratified OC scaffolds in clinical application.Biomimetic OC scaffolds are attractive to overcome the above problems because of their similar biological and mechanical properties with native OC tissue.As a consequence,the researches on biomimetic design to achieve the tissue function of each layer,and additive manufacture(AM)to accomplish composition switch and ultrastructure of personalized OC scaffolds have made a remarkable progress.In this review,the design methods of biomaterial and structure as well as computer-aided design,and performance prediction of biopolymer-based OC scaffolds are presented;then,the characteristics and limitations of AM technologies and the integrated manufacture schemes in OC tissue engineering are summarized;finally,the novel biomaterials and techniques and the inevitable trends of multifunctional bio-manufacturing system are discussed for further optimizing production of tissue engineering OC scaffolds.

关 键 词：Osteochondral tissue Biomimetic scaffold Additive manufacture Integrated manufacture 

分 类 号：R318.08[医药卫生—生物医学工程] TQ317[医药卫生—基础医学]