叶酸修饰白花丹素人血清白蛋白纳米粒的制备及抗肿瘤活性研究  

Preparation of Folate Modified Plumbagin-Loaded Human Serum Albumin Nanoparticles and Study on its Antitumor Activity

作　　者：盖爽爽 覃逸明[1,2] 张鹏 蒋才云[1,2] 江名 Gai Shuangshuang;Qin Yiming;Zhang Peng;Jiang Caiyun;Jiang Ming(Key Laboratory for Research and Development of Characteristic Yao,Guangxi science&technology Normal University;School of food and biochemical engineering,Guangxi science&technology Normal University,Laibin 545004,China)

机构地区：[1]广西科技师范学院特色瑶药资源研究与开发校级重点实验室,广西来宾545004 [2]广西科技师范学院食品与生化工程学院,广西来宾545004

出　　处：《山东化工》2021年第10期22-24,共3页Shandong Chemical Industry

基　　金：广西高校中青年教师科研基础能力提升项目(2019KY0853,2020KY23016)。

摘　　要：为提高白花丹素的抗肿瘤活性,本文构建了叶酸修饰的人血清白蛋白纳米粒运输白花丹素。体外活性实验表明,FA-HSA-白花丹素NPs与裸药白花丹素相比,对MCF-7细胞毒性明显增强,活性提高接近2倍,而对人胚肺细胞WI-38的毒性无明显变化。To improve anti-tumor activity of plumbagin,human serum albumin nanoparticles(NPs)modified with folic acid were constructed to transportplumbagin.The NPs size of FA-HSA-plumbaginwas about 120 nm.The activity experiments in vitro showed that FA-HSA-plumbagin NPs significantly enhanced the cytotoxicity of MCF-7 and the activity was nearly 2 times higher than that of nudeplumbagin,while the toxicity of FA-HSA-plumbagin on human embryonic lung cells WI-38 was not significantly changed.

关 键 词：白花丹素 叶酸 人血清白蛋白纳米粒 抗肿瘤 

分 类 号：R979.1[医药卫生—药品] R285.5[医药卫生—药学]