Advance in the understanding of vasovagal syncope in children and adolescents  

作　　者：Hong-Xia Li Lu Gao Yue Yuan 

机构地区：[1]Department of Cardiology,National Center for Children's Health,Beijing Children's Hospital,Capital Medical University,Beijing,China

出　　处：《World Journal of Pediatrics》2021年第1期58-62,共5页世界儿科杂志（英文版）

摘　　要：Background Vasovagal syncope(VVS)accounts for 60-80% of cases of neurally mediated syncope.VVS results from acute orthostatic intolerance and recurrent syncopal attacks,which can seriously affect an individual's quality of life.In addition,some children even experience trauma during attacks.Therefore,it is particularly important to clarify the pathogenesis of VVS.The aim of our study is to reveal the latest research progress of VVS.Data sources Literature that involved the pathogenesis of VVS were selected from Cochrane Library(1990-2019),EMBASE(1991-2019)and PubMed(1968-2019)databases.Results Hypovolemia,autonomic dysfunction,vasomotor dysfunction,baroreceptor reflex abnormalities,endothelial dys-function,serotonin surges,and gut microbiota were involved in the underlying mechanism of VVS.Conclusions VVS is not always a benign prognosis.Various aspects were involved in its pathogenesis.Bezold-Jarish reflex,dysfunction of the autonomic nervous system,genetic factors and so on played important roles in VVS;however,the mecha-nism remains unclear.

关 键 词：Autonomic nervous system Bezold-Jarish reflex CHILDREN Genetic pathogenesis Vasovagal syncope 

分 类 号：R725[医药卫生—儿科]