COVID-19 and congenital heart disease:a case series of nine children  

作　　者：Elmira Haji Esmaeil Memar Babak Pourakbari Mojtaba Gorgi Meisam Sharifzadeh Ekbatani Amene Navaeian Mahmoud Khodabandeh Shima Mahmoudi Setareh Mamishi 

机构地区：[1]Pediatrics Center of Excellence,Children's Medical Center,Tehran University of Medical Sciences,Tehran,Iran [2]Pediatric Infectious Disease Research Center,Tehran University of Medical Science,Tehran,Iran [3]Division of Pediatric Intensive Care Unit,Pediatrics Center of Excellence,Children's Medical Center,Tehran University of Medical Sciences,Tehran,Iran [4]Department of Infectious Diseases,Pediatrics Center of Excellence,Children's Medical Center,Tehran University of Medical Sciences,Tehran,Iran

出　　处：《World Journal of Pediatrics》2021年第1期71-78,共8页世界儿科杂志（英文版）

基　　金：supported by a grant(grant number:99-1-149-47172)from Tehran University of Medical Sciences to Dr.Setareh Mamishi.

摘　　要：Background Coronavirus disease 2019(COVID-19)is the current pandemic disease without any vaccine or efficient treat-ment to rescue the patients.Underlying diseases predispose the patients to a more severe disease and to a higher mortality rate.However,little evidence exists about COVID-19 outcomes in the pediatric population with congenital heart disease(CHD).Here,we report nine children with COVID-19 and concomitant CHD.Methods Our study included nine children with COVID-19 and concomitant CHD who were admitted to Children Medical Center Hospital during March and April 2020.The patients were classified based on the final outcome(death),and their clinical sign and symptoms,type of CHD,and drugs administered were compared.Results Among the nine patients,two died and we compared different characteristics,laboratory results and clinical findings of these cases based on the mortality.The deceased patients had severe types of CHD,worse arterial blood gases,severe clinical symptoms,higher mean level of partial thromboplastin time and C-reactive protein,and required more medications.Conclusions The present study showed that the general consideration of mild COVID-19 in children does not include patients with CHD and that it is necessary to pay greater attention to children with CHD to determine guidelines for treatment of COVID-19 in these children.Owing to the scarcity of CHD and COVID-19,we reported only nine cases.However,further studies are highly required in this regard.

关 键 词：Congenital heart disease Coronavirus disease 2019 PEDIATRICS 

分 类 号：R725.4[医药卫生—儿科]