醋酸泼尼松联合雷公藤多苷治疗毒性弥漫性甲状腺肿的临床分析  

Clinical effect of prednisone acetate combined with tripterygium wilfordii polyglycoside in treatment of toxic diffuse goiter

作　　者：张微[1] 叶水英 陈婷 ZHANG Wei;YE Shuiying;CHEN Ting(The Third Affiliated Hospital of Gannan Medical University,Ganzhou 341000,China;不详)

机构地区：[1]赣南医学院第三附属医院,江西赣州341000

出　　处：《现代医院》2021年第5期815-816,820,共3页Modern Hospitals

基　　金：江西省中医药管理局科技计划项目(2020A0084)。

摘　　要：目的探究应用醋酸泼尼松与雷公藤多苷治疗毒性弥漫性甲状腺肿患者的价值。方法选自2018年1月—2020年3月医院门诊随诊毒性弥漫性甲状腺肿患者89例,随机分为2组,44例采用甲巯咪唑治疗者为常规组,另45例在此基础上加用醋酸泼尼松与雷公藤多苷治疗者为研究组。比较分析两组患者的治疗效果以及治疗前后血清炎症因子的变化。结果经治疗后,研究组治疗总有效率明显高于常规组;研究组的白细胞介素-17(IL-17)、白细胞介素-22(IL-22)和肿瘤坏死因子(TNF-α)明显低于常规组,差异均具有统计学意义(均P<0.05)。结论醋酸泼尼松与雷公藤多苷联合治疗毒性弥漫性甲状腺肿患者能够有效抑制炎性症状的持续发展,同时提高临床治疗效果。Objective To explore the clinical value of prednisone acetate combined with tripterygium glycosides in the treatment of toxic diffuse goiter.Methods A total of 89 patients with toxic diffuse goiter in our department from January 2018 to March 2020 were randomly divided into 2 groups, equally, the conventional group, and study group. The former was treated with methimazole and the latter was with prednisone acetate plus Tripterygium wilfordii polyglycoside on the base of methimazole. The two groups were compared in terms of the therapeutic effect and the changes of serum inflammatory factors before and after treatment.Results The total treatment efficiency in the study group was significantly higher than that in the conventional group. After treatment, the levels of interleukin-17(IL-17), interleukin-22(IL-22) and tumor necrosis factor(TNF-α) in the study group were significantly lower than the conventional group(P<0.05).Conclusion Prednisone acetate combined with tripterygium glycosides is effective in the treatment of toxic diffuse goiter by effectively inhibiting the development of inflammatory symptoms and improving the clinical treatment effect.

关 键 词：毒性弥漫性甲状腺肿 炎症因子 治疗效果 醋酸泼尼松 雷公藤多苷 应用价值 

分 类 号：R582[医药卫生—内分泌] R453[医药卫生—内科学]