扩散峰度成像在评估甲状腺相关性眼病患者视路损伤的应用研究  

Application of Diffusion Kurtosis Imaging in Evaluating Visual Pathway Injury in Patients with Thyroid-related Ophthalmopathy

作　　者：廖炯[1] 蒲学佳 胡元明[1] 吕涵青[1] 李主镜 王小珍[1] LIAO Jiong;PU Xue-jia;HU Yuan-ming;LYU Han-qing;LI Zhu-jing;WANG Xiao-zhen(Department of Radiology,Shenzhen Traditional Chinese Medical Hospital,Shenzhen 518033,Guangdong Province,China)

机构地区：[1]深圳市中医院放射科,广东深圳518033

出　　处：《中国CT和MRI杂志》2021年第7期40-42,50,共4页Chinese Journal of CT and MRI

摘　　要：目的探索扩散峰度成像(DKI)在研究甲状腺相关性眼病患者视路损伤中的应用价值。方法本研究前瞻性收集30例甲状腺相关性眼病患者及30例正常自愿者,均行颅脑常规MRI平扫及DKI检查。应用扩散峰度成像(DKI)定量测量视路各区域的部分各向异性(FA)值、平均峰度(MK)值和平均扩散率(MD),定量分析视路各区域微观结构的改变。结果甲状腺相关性眼病患者视神经、视束、外侧膝状体、视辐射中的某个或多个区域的MK、FA、MD值有不同程度降低,其中MK值降低最显著。结论扩散峰度成像(DKI)能定量显示视路各区域微观结构的改变,为临床早期诊断甲状腺相关性眼病患者视路损伤提供了参考依据。Objective To explore the application value of diffusion kurtosis imaging(DKI)in the study of visual pathway injury in patients with thyroid-related ophthalmopathy.Methods In this study,30 patients with thyroid-related ophthalmopathy and 30 normal volunteers were prospectively collected.Routine MRI and DKI examinations were performed on the brain.Diffusion kurtosis imaging(DKI)was used to quantitatively measure the ractional anisotropy(FA),mean kurtosis(MK),and mean diffusion(MD)of each region of the visual pathway,and quantitatively analyze the changes in the microstructure of each region of the visual pathway.Results In patients with thyroid-associated ophthalmopathy,the values of Mk,FA,and MD in one or more areas of optic nerve,optic tract,lateral geniculate body,and optic radiation decreased to different degrees,and the decrease of Mk value was the most significant.Conclusion Diffusion kurtosis imaging(DKI)can quantitatively display the changes in the microscopic structure of the visual pathway,which provides a reference for the early diagnosis of visual pathway injury in patients with thyroid-related ophthalmopathy.

关 键 词：扩散峰度成像 甲状腺相关性眼病 视路损伤 

分 类 号：R322.51[医药卫生—人体解剖和组织胚胎学]