肠道菌群参与糖尿病肾病的发病机制研究进展  

The Research Progress of Intestinal Flora in the Pathogenesis of Diabetic Nephropathy

作　　者：郭鑫 吴飞飞[2] GUO Xin;WU Feifei(Changzhi Medical College,Changzhi 046000,China)

机构地区：[1]长治医学院,山西长治046000 [2]长治医学院附属和平医院

出　　处：《中国医学创新》2021年第14期184-188,共5页Medical Innovation of China

基　　金：山西省卫生健康委科研课题(2018127)。

摘　　要：2型糖尿病(type 2 diabetes mellitus,T2DM)是常见疾病,随着患病率不断上升,其慢性并发症也给患者的生活、家庭以及社会带来了沉重的负担。糖尿病肾病是糖尿病常见的严重并发症之一,现已成为终末期肾衰的主要原因,而且缺乏有效的治疗手段,目前主要以降糖、降压、调脂为主,但是传统的治疗方法并不能阻止糖尿病肾病进展,因此有必要探索新的研究方向以期早发现早预防。目前人体内肠道菌群多样性、组成及其代谢和免疫特性与2型糖尿病的发生成为关注的研究热点。本文总结了肠道菌群参与糖尿病肾病发生的相关致病机制。Type 2 diabetes mellitus(T2DM)is a common disease.As the prevalence rate continues to rise,its chronic complications also put a heavy burden on the patient’s own life,family and society.Diabetic nephropathy is one of the common serious complications of diabetes,and it has become the main cause of end-stage renal failure,and there is a lack of effective treatment.At present,the main treatment methods are hypoglycemic,hypotensive,and lipid-lowering,but traditional treatment methods can not prevent the progress of diabetic nephropathy,so it is necessary to explore new research directions with a view to early detection and early prevention.Now,the diversity,composition,metabolic and immune characteristics of intestinal flora in human body and the occurrence of type 2 diabetes mellitus have become the focus of research.This article summarizes the related pathogenic mechanism of intestinal flora involved in the occurrence of diabetic nephropathy.

关 键 词：肠道菌群 2型糖尿病 糖尿病肾病 粪便菌群移植 

分 类 号：R587.2[医药卫生—内分泌] R692.9[医药卫生—内科学]