干细胞-3D支架复合物在伤口敷料中的应用  

Application of stem cells - 3D scaffold complex in wound dressing

作　　者：刘凤琴 王淞 Liu Fengqin;Wang Song(Department of Stomach/Thyroid/Vascular Surgery,Chongqing University Three Gorges Hospital,Chongqing 404000,China)

机构地区：[1]重庆大学附属三峡医院(胃/甲状腺/血管外科),404000

出　　处：《国际外科学杂志》2021年第5期339-345,共7页International Journal of Surgery

摘　　要：大面积创伤或难治性创面的临床治疗十分棘手,寻找合适的伤口敷料对伤口愈合十分重要。干细胞可分泌表达伤口愈合所必需的多种细胞因子,并能在三维(3D)支架材料中较长时间地生长增殖,维持其应有的结构和功能。将干细胞-3D支架复合物以湿润的敷料形式移植于皮肤创面,可显著提高干细胞移植效率,缩短伤口愈合时间,并能减轻瘢痕形成。干细胞-支架复合物或许可成为良好的伤口敷料。该文主要就伤口敷料的选择及干细胞-3D支架复合物作为伤口敷料的研究现状进行综述,旨在为干细胞-3D支架复合物的临床应用提供依据。The clinical treatment of large-area trauma or intractable wound is very difficult.Finding a suitable wound dressing is very important for wound healing.Stem cells can secrete and express a variety of cytokines necessary for wound healing,and can grow and proliferate for a long time in three-dimensional(3D)scaffold materials to maintain their proper structure and function.A large number of studies have shown that transplanting stem cells-3D scaffold complex into the skin wound in the form of a moist dressing can significantly improve the efficiency of stem cells transplantation,shorten the wound healing time,and reduce scar formation.Stem cells-scaffold complex are likely to be a good wound dressing.This article mainly summarizes the selection of wound dressing and the research status of stem cells-3D scaffold complex as a wound dressing,aiming to provide a theoretical basis for the clinical application of stem cells-3D scaffold complex.

关 键 词：创伤和损伤 生物敷料 干细胞 3D 细胞支架 

分 类 号：R641[医药卫生—外科学]