宫内感染产妇血清及羊水Clara细胞蛋白16、肺表面活性蛋白A与新生儿肺损伤的关系  

Correlations between Clara Cell Protein 16 and Pulmonary Surfactant Protein A in Serum and Amniotic Fluid of Pregnant Women with Intrauterine Infection and Neonatal Lung Injury

作　　者：王芳芳 张涛 王晓玲 WANG Fang-fang;ZHANG Tao;WANG Xiao-ling(Department of Obstetrics,the 3201 Hospital of Hanzhong City,Hanzhong,Shaanxi 723000,China;Department of Urinary Surgery,the 3201 Hospital of Hanzhong City,Hanzhong,Shaanxi 723000,China)

机构地区：[1]汉中市三二〇一医院产科,陕西汉中723000 [2]汉中市三二〇一医院泌尿外科,陕西汉中723000

出　　处：《临床误诊误治》2021年第6期96-100,共5页Clinical Misdiagnosis & Mistherapy

基　　金：三二〇一医院科研基金项目(3201YK201701)。

摘　　要：目的探讨宫内感染产妇血清及羊水Clara细胞蛋白16(CC16)、肺表面活性蛋白A(SP-A)与新生儿肺损伤的关系。方法选取2018年1月—2020年9月收治的136例宫内感染产妇及肺损伤新生儿为研究组,70例宫内感染产妇及未发生肺损伤的健康新生儿为对照组。比较两组产妇血清及羊水CC16与SP-A水平,以及新生儿的血气分析指标。分析血清及羊水CC16、SP-A与新生儿肺损伤指标相关性,并应用受试者工作特征(ROC)曲线分析其预测新生儿肺损伤的价值。结果研究组产妇血清及羊水CC16、SP-A水平均低于对照组(P<0.01)。研究组新生儿动脉血氧分压(PaO_( 2))、血氧饱和度(SaO_( 2))、氧合指数(PaO_( 2)/FiO_( 2))均低于对照组,二氧化碳分压(PaCO_( 2))高于对照组(P<0.01)。宫内感染产妇血清及羊水CC16、SP-A水平与新生儿PaO_( 2)/FiO_( 2)呈正相关(P<0.01)。血清CC16预测新生儿肺损伤灵敏度、特异度分别为75.71%、64.71%,血清SP-A分别为80.00%、75.74%,羊水CC16分别为75.71%、71.32%,羊水SP-A分别为85.71%、78.68%。结论宫内感染产妇血清及羊水CC16、SP-A与新生儿肺损伤密切相关,或可作为预测宫内感染新生儿是否发生肺损伤的辅助指标。Objective To investigate correlations between Clara cell protein 16(CC16)and pulmonary surfactant protein A(SP-A)in serum and amniotic fluid of pregnant women with intrauterine infection and neonatal lung injury.Methods From January 2018 to September 2020,A total of 136 pregnant women with intrauterine infection and their neonates with lung injury were enrolled as research group,while other 70 pregnant women with intrauterine infection and their healthy neonates without lung injury were enrolled as control group.CC16 and pulmonary SP-A levels in serum and amniotic fluid,and neonatal blood gas analysis indexes were compared between two groups.Correlations between CC16 and pulmonary SP-A levels in serum and amniotic fluid and neonatal lung injury were analyzed,and their values in prediction of neonatal lung injury were analyzed by using receiver operating characteristic(ROC)curve.Results In research group,CC16 and pulmonary SP-A levels in serum and amniotic fluid were significantly lower than those in control group(P<0.01);levels of neonatal arterial partial pressure of oxygen(PaO_( 2)),blood oxygen saturation(SaO_( 2))and oxygenation index(PaO_( 2)/FiO_( 2))of neonates were significantly lower than those in control group,while partial pressure of carbon dioxide(PaCO_( 2))level was significantly higher than that in control group(P<0.01).Serum and amniotic fluid CC16 and pulmonary SP-A levels of pregnant women with intrauterine infection were positively correlated with PaO_( 2)/FiO_( 2) in neonates(P<0.01).The sensitivity and specificity of serum CC16 in prediction of neonatal lung injury were 75.71%and 64.71%respectively,and those by serum pulmonary SP-A were 80.00%and 75.74%respectively;the sensitivity and specificity of amniotic fluid CC16 were 75.71%and 71.32%respectively,and those by amniotic fluid pulmonary SP-A were 85.71%and 78.68%respectively.Conclusion CC16 and pulmonary SP-A in serum and amniotic fluid of pregnant women with intrauterine infection are closely related with neonatal lung injury,which may be

关 键 词：新生儿肺损伤 宫内感染 Clara细胞蛋白16 表面活性蛋白A 血气分析 ROC曲线 

分 类 号：R722.1[医药卫生—儿科]