泼尼松与黄芪注射液联合治疗对系统性红斑狼疮患者抗中性粒细胞胞浆抗体阳性检出率的改善作用  

An analysis of the effect of combined treatment of prednisone and astragalus injection on the positive detection rate of antineutrophil cytoplasmic antibodies in patients with systemic lupus erythematosus

作　　者：何浩[1] 杨惠琴[2] 邹荣[2] HE Hao;YANG Huiqin;ZOU Rong(Department of Rheumatology and Immunology,Wuhan First Hospital,Wuhan 430000,China;不详)

机构地区：[1]武汉市第一医院风湿免疫科,武汉430000 [2]武汉市第一医院肾内科,武汉430000

出　　处：《实用医学杂志》2021年第11期1481-1484,共4页The Journal of Practical Medicine

基　　金：国家自然科学基金资助项目(编号:81600530)。

摘　　要：目的研究泼尼松联合黄芪注射液治疗系统性红斑狼疮对抗中性粒细胞胞浆抗体(antineu⁃trophil cytoplasmic antibody,ANCA)阳性检出率的改善作用。方法选取2017年5月至2020年6月期间在本院接受治疗的86例系统性红斑狼疮患者为研究对象,按随机数字表法分为两组,各43例。对照组采用泼尼松治疗,观察组加用黄芪注射液,对比两组治疗效果、不良反应、复发率及治疗前后ANCA阳性检出率、SLEDAI评分、24 h尿蛋白、炎性因子。结果与对照组比较(76.74%),观察组(95.35%)治疗总有效率更高(P<0.05);与对照组比较,观察组治疗后SLEDAI评分、24 h尿蛋白水平均更低(P<0.05);与对照组比较,观察组治疗后IL⁃10和β⁃arrestin1水平均更低,IL⁃12水平更高(P<0.05);与对照组比较(30.23%),观察组(6.98%)不良反应发生率更低(P<0.05);与对照组比较(23.26%),观察组(4.65%)复发率更低(P<0.05);与对照组比较(27.91%),观察组(6.98%)ANCA阳性检出率更低(P<0.05)。结论泼尼松联合黄芪注射液治疗系统性红斑狼疮患者,可有效降低复发率,调节免疫指标,不良反应少。Objective To study the effect of prednisone combined with astragalus injection on the positive detection rate of antineutrophil cytoplasmic antibody(ANCA)in systemic lupus erythematosus.Methods A total of 86 patients with systemic lupus erythematosus who had been treated in our hospital from May 2017 to June 2020 were selected as research objects,and they were divided into two groups according to a random number table,with 43 in each group.The control group was treated with prednisone,while the study group was treated with astragalus injection.The efficacy,adverse reactions,recurrence rate,pretherapeutic and post⁃therapeutic positive detection rate of ANCA,SLEDAI score,24⁃hour urine protein,and inflammatory cytokines were compared between the two groups.Results As compared with the control group(76.74%),the study group(95.35%)had a higher total efficacy of treatment(P<0.05).As compared with the control group,the study group had lower SLEDAI scores and 24⁃hour urine protein levels after treatment(P<0.05).As compared with the control group,the study group has lower levels of IL⁃10 andβ⁃arrestin1 but higher IL⁃12 levels(P<0.05).As compared with that in the control group(30.23%),the incidence of adverse reactions was lower in the study group(6.98%)(P<0.05).As compared with the control group(23.26%),the study group(4.65%)had a lower recurrence rate(P<0.05).As compared with that in the control group(27.91%),the positive detection rate of ANCA was lower in the study group(6.98%)(P<0.05).Conclusions Prednisone combined with astragalus injection in the treatment of patients with systemic lupus erythematosus can effectively reduce the recurrence rate and regulate immune indexes,and it has less adverse reactions.

关 键 词：泼尼松 黄芪注射液 联合治疗 系统性红斑狼疮 抗中性粒细胞胞浆抗体 阳性检出率 

分 类 号：R593.241[医药卫生—内科学]