神经莱姆病实验室诊断方法研究进展  

Advances in laboratory diagnosis of Lyme neuroborreliosis

作　　者：徐鑫 张宇[1,2,3] 岳鹏 曹文静 陈泰桂 李连保 罗丽莎 计震华 简苗苗 丁喆 宝福凯 柳爱华[2,3,5] XU Xin;ZHANG Yu;YUE Peng;CAO Wen-jing;CHEN Tai-gui;LI Lian-bao;Luo Li-sha;JI Zhen-hua;JIAN Miao-miao;DING Zhe;BAO Fu-kai;LIU Ai-hua(Yunnan Province Key Laboratory for Tropical Infectious Diseases in Universities,Kunming Medical University,Kunming 650500,China;Yunnan Key Laboratory for Children major Diseases Research,Childen Hospital of Kunmng;Department of Microbiology and Immunology,Kunming Medical University;Department of Biochemistry and Molecular Biology,Kunming Medical University;The Institute for Tropical Medicine,Kunming Medical University)

机构地区：[1]云南省高校热带传染病重点实验室昆明医科大学,云南昆明650500 [2]云南省儿童重大疾病研究重点实验室昆明市儿童医院 [3]昆明医科大学病原生物学与免疫学系 [4]昆明医科大学生物化学与分子生物学系 [5]昆明医科大学热带医学研究所

出　　处：《中国病原生物学杂志》2021年第3期363-367,共5页Journal of Pathogen Biology

基　　金：国家自然科学基金项目(No.81560596,81860644);云南省自然科学基金项目[2017FE467-(001),2019FE001(-002)];云南省教育厅科学研究基金项目(No.2020Y0112)。

摘　　要：神经莱姆病是由伯氏疏螺旋体感染引起的神经系统感染性疾病,已引起医学界高度重视。目前实验室对神经莱姆病的检测方法主要有脑脊液生化检测、血清学检测和病原体直接检测等。实验室的诊断结果对确诊该疾病具有重要指导意义,但其诊断方法较少也一直成为该疾病诊断过程中难以攻克的问题。更加全面地了解神经莱姆病的各种检测方法,对于该疾病感染后续诊断和治疗具有重要意义。Lyme neuroborreliosis is an infectious disease of the nervous system caused by a Borrelia burgdorferi infection,and it has garnered considerable attention in medicine.At present,the methods for laboratory detection of Lyme neuroborreliosis mainly include biochemical testing of cerebrospinal fluid,serological testing,and direct pathogen testing.The results of laboratory diagnosis are crucial to the definitive diagnosis of the disease,but the lack of diagnostic methods has hampered the diagnosis of this disease.A more comprehensive understanding of various methods of detecting Lyme neuroborreliosis is crucial to the subsequent diagnosis and treatment of this disease.

关 键 词：神经莱姆病 伯氏疏螺旋体 实验室诊断 综述 

分 类 号：R377.5[医药卫生—病原生物学]