局部枸橼酸钠抗凝在儿童脓毒症连续肾替代治疗应用评价  

Application of topical sodium citrate anticoagulation in continuous renal replacement therapy in children with sepsis

作　　者：劳金泉 屈翔 李华倩 卢霞 LAO Jinquan;QU Xiang;LI Huaqian;LU Xia(Department of Pediatric,Liuzhou Worker’s Hospital,Liuzhou,Guangxi 545027,China)

机构地区：[1]柳州市工人医院儿科,广西柳州545027

出　　处：《医药前沿》2021年第12期11-13,共3页Journal of Frontiers of Medicine

摘　　要：脓毒症是指感染引起的全身性炎症反应综合征,容易导致多器官功能障碍,是儿童重症监护病房危重患儿常见的死亡原因之一。连续性肾脏替代治疗是脓毒症的重要治疗措施之一,它能为原发病的诊治争取更多的时间,而抗凝是保障治疗顺利进行的基本条件。成人脓毒症连续性肾脏替代治疗多推荐使用局部枸橼酸钠抗凝,而儿童使用的经验文献报道较少。本文就儿童脓毒症行连续性肾脏替代治疗时,对应用局部枸橼酸钠抗凝的疗效及其安全性评价进行综述。Sepsis is a systemic inflammatory response syndrome caused by infection,which easily leads to multiple organ dysfunction,and is one of the common causes of death in critically ill children in pediatric intensive care units.Continuous renal replacement therapy is one of the important treatment measures for sepsis,it can gain more time for the diagnosis and treatment of the primary disease,and anticoagulation is the basic condition to ensure the smooth treatment.Continuous renal replacement therapy for adults with sepsis is recommended to use topical sodium citrate as anticoagulant,but there are few empirical reports on the use of topical sodium citrate in children.This article reviews the efficacy and safety of anticoagulation with topical sodium citrate in continuous renal replacement therapy for children with sepsis.

关 键 词：局部枸橼酸钠抗凝 脓毒症 连续性肾脏替代治疗 

分 类 号：R973[医药卫生—药品]