CD24、IL-6和hs-CRP对新生儿急性肺损伤的诊断及预后预测价值  

Diagnostic and prognostic predictive value of CD24,IL-6 and hs-CRP in neonatal acute lung injury

作　　者：王军[1] 孙红[1] WANG Jun;SUN Hong(Department of Clinical Laboratory,Wuhan Children′s Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology,Wuhan,Hubei 430016,China)

机构地区：[1]华中科技大学同济医学院附属武汉儿童医院检验科,湖北武汉430016

出　　处：《国际检验医学杂志》2021年第12期1489-1494,共6页International Journal of Laboratory Medicine

基　　金：华中科技大学同济医学院附属武汉儿童医院院内项目(2017FE006)。

摘　　要：目的探讨CD24、白细胞介素-6(IL-6)、超敏C反应蛋白(hs-CRP)对新生儿急性肺损伤(ALI)的诊断及预后预测价值。方法选取2018年1-12月该院新生儿科收治的ALI患儿152例为研究组,根据引起新生儿ALI的诱因不同将所有患儿又分为间接诱发组128例和直接诱发组24例。另选取同期进行体检的健康新生儿30例作为对照组。检测研究对象单个核细胞中CD24、IL-6水平及血清hs-CRP水平,采用受试者工作特征曲线分析上述指标对新生儿ALI的诊断及预后预测价值。结果与对照组比较,治疗前研究组CD24、IL-6及hs-CRP水平明显升高,差异有统计学意义(P<0.05)。治疗前间接诱发组CD24、IL-6水平高于直接诱发组,hs-CRP水平低于直接诱发组,差异有统计学意义(P<0.05)。治疗后直接诱发组、间接诱发组CD24、IL-6及hs-CRP水平均低于同组治疗前,差异有统计学意义(P<0.05)。治疗前CD24诊断间接诱发性ALI的曲线下面积(AUC)为0.9885,诊断直接诱发性ALI的AUC为0.9833,高于IL-6及hs-CRP。治疗后IL-6预测间接诱发性ALI预后的AUC为0.7272,预测直接诱发性ALI预后的AUC为0.6514,高于CD24和hs-CRP。结论ALI患儿存在CD24、IL-6和hs-CRP水平升高,且经治疗后上述3项指标水平有所下降。CD24是诊断新生儿ALI的良好指标,IL-6对治疗后ALI患儿的预后有一定预测价值。Objective To investigate the diagnostic and prognostic predictive value of CD24,interleukin-6(IL-6),high-sensitivity C-reactive protein(hs-CRP)in neonatal acute lung injury(ALI).Methods A total of 152 children with ALI admitted to the hospital from January to December 2018 were selected as the study group.According to the different causes of neonatal ALI,all the children were divided into indirect induction group(128 cases)and direct induction group(24 cases).In addition,30 healthy newborns who underwent physical examination during the same period were selected as the control group.The levels of CD24,IL-6 in mononuclear cells and hs-CRP in serum were detected,and receiver operating characteristic curve was used to analyze the diagnostic and prognostic predictive value of the above indicators in neonatal ALI.Results Compared with the control group,the levels of CD24,IL-6 and hs-CRP in the study group were significantly increased before treatment,and the differences were statistically significant(P<0.05).Before treatment,the levels of CD24 and IL-6 in the indirect induction group were higher than those in the direct induction group,and the hs-CRP level was lower than that in the direct induction group,the differences were statistically significant(P<0.05).After treatment,the levels of CD24,IL-6 and hs-CRP in the direct induction group and the indirect induction group were lower than those in the same group before treatment,and the differences were statistically significant(P<0.05).Before treatment,the area under the curve(AUC)of CD24 for diagnosing indirectly induced ALI was 0.9885,and the AUC for diagnosing directly induced ALI was 0.9833,which were higher than IL-6 and hs-CRP.After treatment,the AUC of IL-6 predicting the prognosis of indirectly induced ALI was 0.7272,and the AUC of predicting the prognosis of directly induced ALI was 0.6514,which were higher than those of CD24 and hs-CRP.Conclusion The levels of CD24,IL-6 and hs-CRP in children with ALI are elevated,and the levels of the above three indicators d

关 键 词：新生儿 急性肺损伤 CD24 白细胞介素-6 超敏C反应蛋白 

分 类 号：R722.1[医药卫生—儿科]