Presentation and outcomes of chronic rhinosinusitis following liver and kidney transplant  

作　　者：Aviv Spillinger Christopher M.Low Byron M.Smith Janalee K.Stokken Erin K.O'Brien Garret Choby 

机构地区：[1]Deportment of Otoloryngolosy-Head and Neck Surgery,Mayo Clinic,Rochester,MN,55905,USA [2]Biomedical Statistics and Informatics,Mayo Clinic,Rochester,MN,55905,USA

出　　处：《World Journal of Otorhinolaryngology-Head and Neck Surgery》2021年第2期139-145,共7页世界耳鼻咽喉头颈外科杂志（英文）

摘　　要：non-invasive chronic rhinosinusitis(CRS)following liver or kidney transplant and determine factors associated with disease-related complications,selection of endoscopic sinus surgery(ESS),and disease resolution in this population.Study design:Retrospective chart review.Setting:An academic tertiary care center(Mayo Clinic,Rochester,Minnesota).Subjects and methods:Liver and kidney transplant recipients evaluated by Mayo Clinic otolaryngologists for CRS between 1998 and 2018 were identified.Univariate and multivariate logistic regression analyses were used to determine patient factors and treatment modalities associated with developing complications,selection of ESS,and disease resolution.Results:Fifty-seven patients met inclusion criteria.No patients developed intraorbital or intracranial complications of their CRS.Multivariate modeling demonstrated that the presence of polyps(P=0.036)was associated with undergoing ESS within one year of presentation.A higher Lund-Mackay(LM)computed tomography score(P=0.023)and older age(P=0.018)were significantly associated with decreased disease resolution.No other factors were significantly associated with the use of endoscopic sinus surgery within one year of otolaryngology presentation or resolution of CRS in this cohort.Conclusion:The risk of developing CRS-related intraorbital or intracranial complications in this immunecompromised patient cohort may be lower than originally thought.For liver-and kidney-recipients stable on immunosuppressive medication for many years,prognostic factors for CRS may mirror those for immunocompetent patients.

关 键 词：RHINOSINUSITIS Chronic rhinosinusitis Non-invasive rhinosinusitis Kidney transplant Liver transplant IMMUNOCOMPROMISED IMMUNOSUPPRESSED 

分 类 号：R765.4[医药卫生—耳鼻咽喉科]