酸枣仁汤调节睡眠防治阿尔茨海默病理论探讨  

Theoretical study of Suanzaoren Decoction on prevention and treatment of Alzheimer’s disease by regulating sleep

作　　者：刘玲[1] 吴东南[2] 方洁 何俊 肖潇[1] 董欢欢[1] 王平[1] LIU Ling;WU Dong-nan;FANG Jie;HE Jun;XIAO Xiao;DONG Huan-huan;WANG Ping(Department of Encephalopathy,Hubei Provincial Hospital of Traditional Chinese Medicine,Wuhan 430065,China;Department of Traditional Chinese Medicine,Yuebei People’s Hospital,Shaoguan 512400,China)

机构地区：[1]湖北省中医院脑病科,武汉430065 [2]粤北人民医院中医科,韶关512400

出　　处：《中华中医药杂志》2021年第5期2995-2997,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：韶关市卫生健康局科研项目(No.Y19016);广东省中医药管理局科研项目(No.20201347);国家自然科学基金项目(No.81573865)。

摘　　要：睡眠障碍与阿尔茨海默病(AD)关系密切,一方面,睡眠障碍是AD重要的临床表现,改善睡眠是治疗AD重要的目标;另一方面,睡眠障碍是AD潜在的危险因素,改善睡眠是预防AD重要的策略。中医认为阴血在睡眠与认知中起重要作用,是睡眠、学习记忆功能共同的物质基础,阴血不足是睡眠障碍与AD的共同的关键病机。基于中医异病同治、证同治同思想,养血滋阴法成为防治睡眠障碍与AD重要的治法,近年来的动物研究也表明养血滋阴法代表方酸枣仁汤在调节睡眠的同时,有脑保护作用。但中医养血滋阴法防治AD、中医从睡眠防治AD的有效性仍缺乏有力的临床证据支持,其可能介导的作用机制仍待进一步的探讨。Sleep disorder is closely related to Alzheimer’s disease(AD).On one hand,sleep disorder is an important clinical manifestation of AD,and improving sleep quality is an important goal in the treatment of AD.On the other hand,sleep disorder is a potential risk factor for AD,and improving sleep quality is an important strategy to prevent AD.Traditional Chinese medicine believes that blood plays an important role in sleep and cognition,is the common material basis of sleep,learning and memory function.Yin-blood deficiency is the common key pathogenesis of sleep disorder and AD.Based on the idea of treating different diseases with same method,the method of nourishing yin-blood has become an important method for preventing and treating sleep disorders and AD.Animal studies in recent years have also shown that the method of nourishing yin-blood method,represents Suanzaoren Decoction,which has the effect of brain protection while regulating sleep.However,the effectiveness of nourishing yin-blood method in preventing and treating AD,the prevention and treatment of AD from sleep still lacks strong clinical evidence,also the possible mechanism of its mediation remains to be further explored.

关 键 词：阿尔茨海默病 睡眠障碍 阴血亏虚 养血滋阴法 酸枣仁汤 异病同治 

分 类 号：R277.7[医药卫生—中医学]