Iron-Catalyzed Intramolecular C-H Amidation of N-Benzoyloxyureas  

作　　者：Dayou Zhong Lin-Yang Wu Xing-Zhen Wang Wen-Bo Liu 

机构地区：[1]Sauvage Center for Molecular Sciences,Engineering Research Center of Organosilicon Compounds&Materials(Ministry of Education),College of Chemistry and Molecular Sciences,Wuhan University,Wuhan,Hubei,430072 China

出　　处：《Chinese Journal of Chemistry》2021年第4期855-858,共4页中国化学（英文版）

基　　金：the financial support from NSFC(Nos.21971198 and 21772148);Large-scale Instrument and Equipment Sharing Foundation of Wuhan University and the Natural Science Foundation of Hubei Province(Grant No.2020CFA036)。

摘　　要：Main observation and conclusion A redox-neutral Fe-catalyzed intramolecular C-H amidation of N-benzoyloxyureas is described.This methodology employs a simple iron complex in situ generated from Fe(OTf)2 and bipyridine as the catalyst and N-benzoyloxyureas as the nitrene precursors without using exogenous oxidants.An array of cyclic ureas were synthesized via aliphatic C(sp^(3))-H amidation in excellent yields.In addition,this catalytic system is also amenable to aryl C(sp^(2))-H nitrene insertion to provide benzimidazolones in moderate yields.

关 键 词：C-H activation AMINATION CYCLIZATION Iron catalysis Nitrene insertion 

分 类 号：O62[理学—有机化学]