Synthesis of 3-Methylthio-benzo[b]furans/Thiophenes via Intramolecular Cyclization of 2-Alkynylanisoles/Sulfides Mediated by DMSO/DMSO-d_(6) and SOCl_(2)  

作　　者：Beibei Zhang Xiaoxian Li Xuemin Li Fengxia Sun Yunfei Du 

机构地区：[1]Tianjin Key Laboratory for Modern Drug Delivery&High-Efficiency,School of Pharmaceutical Science and Technology,Tianjin University,Tianjin,300072 China [2]College of Chemical and Pharmaceutical Engineering,Hebei University of Science and Technology,Hebei Research Center of Pharmaceutical and Chemical Engineering,Shijiazhuang,Hebei,050018 China

出　　处：《Chinese Journal of Chemistry》2021年第4期887-895,共9页中国化学（英文版）

基　　金：We acknowledge the National Natural Science Foundation of China(No.21472136)for financial support.

摘　　要：Main observation and conclusion The reaction of 2-alkynylanisoles/sulfides with SOCl_(2) and DMSO was conducted to conveniently furnish the biologically interesting 3-(methylthio)-benzo[b]furans/thiophenes via intramolecular cyclization.DMSO acts as a solvent as well as a sulfur source and can also be replaced with DMSO-d_(6),enabling the incorporation of the SCD3 moiety of DMSO-d_(6) to the 3-position of the heterocyclic frameworks.

关 键 词：3-Methylthio-benzo[b]furans/Thiophenes 2-Alkynylanisoles/Sulfides DMSO/DMSO-d_(6)SOCl_(2) Interrupted pummerer process 

分 类 号：O62[理学—有机化学]