Metal-Free Catalyzed Cyclization of N-Methoxybenzamides to Construct Quaternary Carbon-Containing Isoindolinones  

作　　者：Lin-Bao Zhang Zi-Chen Wang Sheng-Zheng Sun Shao-Fei Ni Li-Rong Wen Ming Li 

机构地区：[1]State Key Laboratory Base of Eco-Chemical Engineering,College of Chemistry and Molecular Engineering,Qingdao University of Science and Technology,Qingdao,Shandong 266042,China [2]Department of Chemistry and Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province,Shantou University,Shantou,Guangdong 515063,China

出　　处：《Chinese Journal of Chemistry》2021年第4期903-908,共6页中国化学（英文版）

基　　金：the National Natural Science Foundation of China(Nos.21801152 and 21572110);the Natural Science Foundation of Shandong Province(Nos.ZR2019BB005 and ZR2019MB010)for financial support;Shao-Fei Ni acknowledge funding from the STU Scientific Research Foundation for Talents(NTF20022).

摘　　要：Main observation and conclusion Through the intramolecular cyclization of N-methoxybenzamides,a simple and efficient method for constructing valuable isoindolinones under metal-free conditions was developed.The reaction was featured by employing low-cost catalyst,simple operation,100%atomic economy and excellent regioselectivity.Moreover,a detailed computational study on the reaction system has been performed to clarify the mechanism.

关 键 词：Quaternary carbe Density functional theory ANNULATION ALKYNES Synthetic methods 

分 类 号：O62[理学—有机化学]