Synthesis of Acrylonitriles via Mild Base Promoted Tandem Nucleophilic Substitution-Isomerization ofα-Cyanohydrin Methanesulfonates  

作　　者：Shiwen Liu Lingling Meng Xiaojun Zeng Gerald B.Hammond Bo Xu 

机构地区：[1]College of Textiles and Clothing&Key Laboratory for Advanced Technology in Environmental Protection of Jiangsu Province,Yancheng Institute of Technology,Yancheng,Jiangsu 224003,China [2]Key Laboratory of Science and Technology of Eco-Textiles,Ministry of Education,College of Chemistry,Chemical Engineering and Biotechnology,Donghuo University,Shanghai 201620,China [3]Department of Chemistry,University of Louisville,Louisville,Kentucky 40292,United States

出　　处：《Chinese Journal of Chemistry》2021年第4期913-917,共5页中国化学（英文版）

基　　金：the Scientific Research Foundation of Yancheng Institute of Technology(No.1542036);the National Natural Science Foundation of China for financial support(No.NSFC-21472018);the National Science Foundation(NSF,Grant No.CHE-1401700);the Open Fund of Jiangsu Collaborative Innovation Center for Ecological Building Material and Environmental Protection Equipments and Key Laboratory for Advanced Technology in Environmental Protection of Jiangsu Province(No.JH201832);the Funding for School-Level Research Projects of Yancheng Institute of Technology(No.xjr2020011).

摘　　要：Main observation and conclusion We have developed an efficient synthesis of acrylonitriles via mild base promoted tandem nucleophilic substitution-isomerization ofα-cyanohydrin methanesulfonates with alkenylboronic acids.This transition metal-free protocol works under simple and mild conditions and offers good chemical yields for a wide range of substrates and demonstrates good functional group tolerance.

关 键 词：Acrylonitriles Nucleophilic substitution ISOMERIZATION α-Cyanohydrin methanesulfonates Alkenyl boronic acids 

分 类 号：O62[理学—有机化学]