Enantioselective Hydrogenation of Endocyclic Enones:the Solution to a Historical Problem  

作　　者：Qiwei Lang Huaxin Yang Guoxian Gu Qiang Feng Jialin Wen Xumu Zhang 

机构地区：[1]Department of Chemistry,Guangdong Provincial Key Laboratory of Catalysis,Southern University of Science and Technology,1088 Xueyuan Road,Shenzhen,Guangdong,515055 China [2]Academy for Advanced Interdisciplinary Studies,Southern University of Science and Technology.1088 Xueyuan Road,Shenzhen,Guangdong,515055 China

出　　处：《Chinese Journal of Chemistry》2021年第4期933-936,共4页中国化学（英文版）

基　　金：This project was financially supported by the Science,Technology and Innovation Commission of Shenzhen(Nos.KQTD20150717103157174,JCYJ20170817104350391);the National Natural Science Foundation of China(No.21801118);the Guangdong Provincial Key Laboratory of Catalysis(No.2020B121201002).

摘　　要：Main observation and conclusion The enantioselective hydrogenation of endocyclic enones has been a historical problem for homogeneous catalysis.We herein report an efficient method to reduce endocyclic enones with molecular hydrogen.Catalyzed by a rhodium/Zhaophos complex,a variety of enones with five-,six-or seven-member ring were hydrogenated with high enantioselectivity(92%-99%ee).Excellent chemo-and enantioselectivity demonstrated this method was successfully applied in the enantioselective hydrogenation of citral to produce enantio-enriched citronellal.

关 键 词：Asymmetric catalysis HYDROGENATION Cyclic enone RHODIUM Citral reduction 

分 类 号：O62[理学—有机化学]