Direct Electrochemical Synthesis of Sulfur-Containing Triazolium Inner Salts  

作　　者：Yueheng Li Zhixing Huang Guangquan Mo Wei Jiang Chengwei Zheng Pengju Feng Zhixiong Ruan 

机构地区：[1]Key Laboratory of Molecular Target&Clinical Pharmacology and the State Key Laboratory of Respiratory Disease,School of Pharmaceutical Sciences&the Fifth Affiliated Hospital,Guangzhou Medical University,Guangzhou,Guangdong 511436,China [2]Department of Chemistry,Jinan University,Guangzhou,Guangdong 510632,China

出　　处：《Chinese Journal of Chemistry》2021年第4期942-946,共5页中国化学（英文版）

基　　金：Support by the National Natural Science Foundation of China(No.21901052);the Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme(2019);the Guangzhou Education Bureau University Scientific Research Project(No.201831845);Guangdong Basic and Applied Basic Research Foundation(No.2020A1515010722)is most gratefully acknowledged.

摘　　要：Main observation and conclusion The electrochemical thiocyanation/cyclization of aldehyde hydrazones was developed under external oxidant-free and catalyst-free conditions.In contrast to previous thiocyanation,this electrosynthetic approach enabled a cascade C-H thiocyanation/cyclization through a mild,direct electrolysis manner in an undivided cell without the additive of halogens and stoichiometric oxidants.In this protocol,commercially available and inexpensive sodium thiocyanate was used,which played a dual role as a thiocyanation reagent and electrolyte.This strategy provides expedient access to functionalized sulfur-containing triazolium inner salts with ample scope and diverse functional group tolerance.Based on the findings of mechanistic studies,a reaction mechanism was proposed.

关 键 词：ELECTROCHEMISTRY THIOCYANATION CYCLIZATION Aldehyde Hydrazone Triazolium 

分 类 号：O62[理学—有机化学]